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Crystal structure of human FPPS in complex with biaryl compound 8e

Source organism: Homo sapiens
Biochemical function: transferase activity, transferring alkyl or aryl (other than methyl) groups
Biological process: isoprenoid biosynthetic process
Cellular component: not assigned

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EC 2.5.1.10: (2E,6E)-farnesyl diphosphate synthase

Reaction catalysed:
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate
Systematic name:
Geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase
Alternative Name(s):
  • FPP synthetase
  • Farnesyl pyrophosphate synthetase
  • Farnesyl-diphosphate synthase
  • Farnesylpyrophosphate synthetase
  • Geranyl transferase I
  • Geranyltranstransferase
  • Prenyltransferase

EC 2.5.1.1: Dimethylallyltranstransferase

Reaction catalysed:
Prenyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate
Systematic name:
Prenyl-diphosphate:isopentenyl-diphosphate prenyltranstransferase
Alternative Name(s):
  • (2E,6E)-farnesyl diphosphate synthetase
  • DMAPP:IPP-dimethylallyltransferase
  • Dimethylallyltransferase
  • Diprenyltransferase
  • Geranyl pyrophosphate synthase
  • Geranyl pyrophosphate synthetase
  • Geranyl-diphosphate synthase
  • Prenyltransferase
  • Trans-farnesyl pyrophosphate synthetase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00348
Domain description: Polyprenyl synthetase
Occurring in:
  1. Farnesyl pyrophosphate synthase
The deposited structure of PDB entry 5djv contains 1 copy of Pfam domain PF00348 (Polyprenyl synthetase) in Farnesyl pyrophosphate synthase. Showing 1 copy in chain A [auth F].

InterPro InterPro annotations
IPR033749
Domain description: Polyprenyl synthetase, conserved site
Occurring in:
  1. Farnesyl pyrophosphate synthase
IPR000092
Domain description: Polyprenyl synthetase
Occurring in:
  1. Farnesyl pyrophosphate synthase
IPR008949
Domain description: Isoprenoid synthase domain superfamily
Occurring in:
  1. Farnesyl pyrophosphate synthase
IPR039702
Domain description: Farnesyl pyrophosphate synthase-like
Occurring in:
  1. Farnesyl pyrophosphate synthase

Structure domain

CATH CATH domain
1.10.600.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Farnesyl Diphosphate Synthase
Homology: Farnesyl Diphosphate Synthase
Occurring in:
  1. Farnesyl pyrophosphate synthase
The deposited structure of PDB entry 5djv contains 1 copy of CATH domain 1.10.600.10 (Farnesyl Diphosphate Synthase) in Farnesyl pyrophosphate synthase. Showing 1 copy in chain A [auth F].

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