Function and Biology

Structure of the extracellular domain of the CD40 in complex with 3H56-5 DAB

Source organism: Homo sapiens
Biochemical function: signaling receptor activity
Biological process: regulation of immune response
Cellular component: external side of plasma membrane

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00020
Domain description: TNFR/NGFR cysteine-rich region
Occurring in:
  1. Tumor necrosis factor receptor superfamily member 5
The deposited structure of PDB entry 5dmj contains 6 copies of Pfam domain PF00020 (TNFR/NGFR cysteine-rich region) in Tumor necrosis factor receptor superfamily member 5. Showing 2 copies in chain C [auth D].

InterPro InterPro annotations
IPR001368
Domain description: TNFR/NGFR cysteine-rich region
Occurring in:
  1. Tumor necrosis factor receptor superfamily member 5
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. 3H65-5 domain antibody (dAb)
IPR020435
Domain description: Tumour necrosis factor receptor 5
Occurring in:
  1. Tumor necrosis factor receptor superfamily member 5
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. 3H65-5 domain antibody (dAb)
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. 3H65-5 domain antibody (dAb)
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. 3H65-5 domain antibody (dAb)
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. 3H65-5 domain antibody (dAb)
IPR034021
Domain description: Tumour necrosis factor receptor 5, N-terminal
Occurring in:
  1. Tumor necrosis factor receptor superfamily member 5

Structure domains

CATH CATH domains
2.10.50.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Tumor Necrosis Factor Receptor, subunit A; domain 2
Homology: Tumor Necrosis Factor Receptor, subunit A, domain 2
Occurring in:
  1. Tumor necrosis factor receptor superfamily member 5
The deposited structure of PDB entry 5dmj contains 6 copies of CATH domain 2.10.50.10 (Tumor Necrosis Factor Receptor, subunit A; domain 2) in Tumor necrosis factor receptor superfamily member 5. Showing 2 copies in chain C [auth D].
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. 3H65-5 domain antibody (dAb)
The deposited structure of PDB entry 5dmj contains 3 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in 3H65-5 domain antibody (dAb). Showing 1 copy in chain B.