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Crystal structure of M. tuberculosis EchA6 bound to C20-CoA

Source organism: Mycobacterium tuberculosis H37Rv
Biochemical function: hydro-lyase activity
Biological process: fatty acid beta-oxidation
Cellular component: peptidoglycan-based cell wall

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EC 4.2.1.17: Enoyl-CoA hydratase

Reaction catalysed:
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O
Systematic name:
(3S)-3-hydroxyacyl-CoA hydro-lyase
Alternative Name(s):
  • 2-enoyl-CoA hydratase
  • 2-octenoyl coenzyme A hydrase
  • Acyl coenzyme A hydrase
  • Beta-hydroxyacid dehydrase
  • Beta-hydroxyacyl-CoA dehydrase
  • Crotonase
  • Crotonyl hydrase
  • D-3-hydroxyacyl-CoA dehydratase
  • ECH
  • Enol-CoA hydratase
  • Enoyl coenzyme A hydrase (D)
  • Enoyl coenzyme A hydrase (L)
  • Enoyl coenzyme A hydratase
  • Enoyl hydrase
  • Hydratase, enoyl coenzyme A
  • Short chain enoyl coenzyme A hydratase
  • Short-chain enoyl-CoA hydratase
  • Trans-2-enoyl-CoA hydratase
  • Unsaturated acyl-CoA hydratase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00378
Domain description: Enoyl-CoA hydratase/isomerase
Occurring in:
  1. Probable enoyl-CoA hydratase EchA6
The deposited structure of PDB entry 5dtw contains 6 copies of Pfam domain PF00378 (Enoyl-CoA hydratase/isomerase) in Probable enoyl-CoA hydratase EchA6. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR018376
Domain description: Enoyl-CoA hydratase/isomerase, conserved site
Occurring in:
  1. Probable enoyl-CoA hydratase EchA6
IPR001753
Domain description: Enoyl-CoA hydratase/isomerase
Occurring in:
  1. Probable enoyl-CoA hydratase EchA6
IPR029045
Domain description: ClpP/crotonase-like domain superfamily
Occurring in:
  1. Probable enoyl-CoA hydratase EchA6

Structure domain

CATH CATH domain
3.90.226.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: 2-enoyl-CoA Hydratase; Chain A, domain 1
Homology: 2-enoyl-CoA Hydratase; Chain A, domain 1
Occurring in:
  1. Probable enoyl-CoA hydratase EchA6
The deposited structure of PDB entry 5dtw contains 6 copies of CATH domain 3.90.226.10 (2-enoyl-CoA Hydratase; Chain A, domain 1) in Probable enoyl-CoA hydratase EchA6. Showing 1 copy in chain C.

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