› 5duw

X-ray diffraction
1.7Å resolution

Crystal structure of the human galectin-4 N-terminal carbohydrate recognition domain in complex with lactose-3'-sulfate

Released:
DOI: 10.2210/pdb5duw/pdb
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PDB entry 5duw coloured by chain, front view.
PDB entry 5duw coloured by chain, side view.
PDB entry 5duw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3'-sulfo-lactose, and 2'-fucosyllactose.
Bum-Erdene K, Leffler H, Nilsson UJ, Blanchard H
OpenAccess logo Sci Rep 6 20289 (2016)
PMID: 26828567

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157475 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Galectin-4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 155 amino acids
Theoretical weight: 17.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P56470 (Residues: 1-155; Coverage: 48%)
Gene name: LGALS4
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: BGC, SGA
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 63.18Å b: 64.05Å c: 64.65Å
α: 90° β: 91.03° γ: 90°
R-values:
R R work R free
0.151 0.149 0.181
Expression system: Escherichia coli

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Citations

4 review citations

Galectin Targeted Therapy in Oncology: Current Knowledge and Perspectives.
Wdowiak et al. (2018)
3 more

4 mentions without citation

What is the Sugar Code?
Gabius et al. (2022)
3 more

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