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Structural and Functional Analysis of Cell Wall-anchored Polypeptide Adhesin BspA in Streptococcus agalactiae.

Rego S, Heal TJ, Pidwill GR, Till M, Robson A, Lamont RJ, Sessions RB, Jenkinson HF, Race PR, Nobbs AH
J Biol Chem 291 15985-6000 (2016)
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Cited: 25 times
EuropePMC logo PMID: 27311712

Abstract

Streptococcus agalactiae (group B Streptococcus, GBS) is the predominant cause of early-onset infectious disease in neonates and is responsible for life-threatening infections in elderly and immunocompromised individuals. Clinical manifestations of GBS infection include sepsis, pneumonia, and meningitis. Here, we describe BspA, a deviant antigen I/II family polypeptide that confers adhesive properties linked to pathogenesis in GBS. Heterologous expression of BspA on the surface of the non-adherent bacterium Lactococcus lactis confers adherence to scavenger receptor gp340, human vaginal epithelium, and to the fungus Candida albicans Complementary crystallographic and biophysical characterization of BspA reveal a novel β-sandwich adhesion domain and unique asparagine-dependent super-helical stalk. Collectively, these findings establish a new bacterial adhesin structure that has in effect been hijacked by a pathogenic Streptococcus species to provide competitive advantage in human mucosal infections.

Articles - 5dz8 mentioned but not cited (3)

  1. Structural and Functional Analysis of Cell Wall-anchored Polypeptide Adhesin BspA in Streptococcus agalactiae. Rego S, Heal TJ, Pidwill GR, Till M, Robson A, Lamont RJ, Sessions RB, Jenkinson HF, Race PR, Nobbs AH. J Biol Chem 291 15985-16000 (2016)
  2. Targeting the BspC-vimentin interaction to develop anti-virulence therapies during Group B streptococcal meningitis. Manzer HS, Villarreal RI, Doran KS. PLoS Pathog 18 e1010397 (2022)
  3. The Group B Streptococcal surface antigen I/II protein, BspC, interacts with host vimentin to promote adherence to brain endothelium and inflammation during the pathogenesis of meningitis. Deng L, Spencer BL, Holmes JA, Mu R, Rego S, Weston TA, Hu Y, Sanches GF, Yoon S, Park N, Nagao PE, Jenkinson HF, Thornton JA, Seo KS, Nobbs AH, Doran KS. PLoS Pathog. 15 e1007848 (2019)


Reviews citing this publication (7)

  1. Group B Streptococcal Maternal Colonization and Neonatal Disease: Molecular Mechanisms and Preventative Approaches. Patras KA, Nizet V. Front Pediatr 6 27 (2018)
  2. Bacterial and Host Determinants of Group B Streptococcal Vaginal Colonization and Ascending Infection in Pregnancy. Brokaw A, Furuta A, Dacanay M, Rajagopal L, Adams Waldorf KM. Front Cell Infect Microbiol 11 720789 (2021)
  3. The Multifaceted Nature of Streptococcal Antigen I/II Proteins in Colonization and Disease Pathogenesis. Manzer HS, Nobbs AH, Doran KS. Front Microbiol 11 602305 (2020)
  4. Streptococcus agalactiae Non-Pilus, Cell Wall-Anchored Proteins: Involvement in Colonization and Pathogenesis and Potential as Vaccine Candidates. Pietrocola G, Arciola CR, Rindi S, Montanaro L, Speziale P. Front Immunol 9 602 (2018)
  5. Interactions between Candida albicans and the resident microbiota. Li H, Miao MX, Jia CL, Cao YB, Yan TH, Jiang YY, Yang F. Front Microbiol 13 930495 (2022)
  6. Interspecies Interactions within the Host: the Social Network of Group B Streptococcus. Mejia ME, Robertson CM, Patras KA. Infect Immun 91 e0044022 (2023)
  7. Lactococcus lactis, an Attractive Cell Factory for the Expression of Functional Membrane Proteins. Frelet-Barrand A. Biomolecules 12 180 (2022)

Articles citing this publication (15)

  1. Bacterial protein domains with a novel Ig-like fold target human CEACAM receptors. van Sorge NM, Bonsor DA, Deng L, Lindahl E, Schmitt V, Lyndin M, Schmidt A, Nilsson OR, Brizuela J, Boero E, Sundberg EJ, van Strijp JAG, Doran KS, Singer BB, Lindahl G, McCarthy AJ. EMBO J 40 e106103 (2021)
  2. Enteric bacteria boost defences against oxidative stress in Entamoeba histolytica. Varet H, Shaulov Y, Sismeiro O, Trebicz-Geffen M, Legendre R, Coppée JY, Ankri S, Guillen N. Sci Rep 8 9042 (2018)
  3. The Streptococcus gordonii Adhesin CshA Protein Binds Host Fibronectin via a Catch-Clamp Mechanism. Back CR, Sztukowska MN, Till M, Lamont RJ, Jenkinson HF, Nobbs AH, Race PR. J. Biol. Chem. 292 1538-1549 (2017)
  4. Coassociation between Group B Streptococcus and Candida albicans Promotes Interactions with Vaginal Epithelium. Pidwill GR, Rego S, Jenkinson HF, Lamont RJ, Nobbs AH. Infect. Immun. 86 (2018)
  5. Genomic and phenotypic diversity of Enterococcus faecalis isolated from endophthalmitis. Chilambi GS, Nordstrom HR, Evans DR, Kowalski RP, Dhaliwal DK, Jhanji V, Shanks RMQ, Van Tyne D. PLoS One 16 e0250084 (2021)
  6. Molecular Characteristics of IS1216 Carrying Multidrug Resistance Gene Cluster in Serotype III/Sequence Type 19 Group B Streptococcus. Zhi Y, Ji HJ, Jung JH, Byun EB, Kim WS, Lin SM, Lim S, Jang AY, Choi MJ, Ahn KB, Lim JH, Song JY, Seo HS. mSphere 6 e0054321 (2021)
  7. Proteomic Characterization of Virulence Factors and Related Proteins in Enterococcus Strains from Dairy and Fermented Food Products. Abril AG, Quintela-Baluja M, Villa TG, Calo-Mata P, Barros-Velázquez J, Carrera M. Int J Mol Sci 23 10971 (2022)
  8. Surface proteins involved in the adhesion of Streptococcus salivarius to human intestinal epithelial cells. Chaffanel F, Charron-Bourgoin F, Soligot C, Kebouchi M, Bertin S, Payot S, Le Roux Y, Leblond-Bourget N. Appl. Microbiol. Biotechnol. 102 2851-2865 (2018)
  9. Enterococcus adhesin PrgB facilitates type IV secretion by condensation of extracellular DNA. Kohler V, Keller W, Grohmann E. Mol. Microbiol. 109 263-267 (2018)
  10. Structural foundation for the role of enterococcal PrgB in conjugation, biofilm formation, and virulence. Sun WS, Lassinantti L, Järvå M, Schmitt A, Ter Beek J, Berntsson RP. Elife 12 RP84427 (2023)
  11. Surface-exposed loops and an acidic patch in the Scl1 protein of group A Streptococcus enable Scl1 binding to wound-associated fibronectin. McNitt DH, Choi SJ, Keene DR, Van De Water L, Squeglia F, Berisio R, Lukomski S. J. Biol. Chem. 293 7796-7810 (2018)
  12. The Fungal Pathogen Candida albicans Promotes Bladder Colonization of Group B Streptococcus. Shing SR, Ramos AR, Patras KA, Riestra AM, McCabe S, Nizet V, Coady A. Front Cell Infect Microbiol 9 437 (2019)
  13. The Group B Streptococcal Adhesin BspC Interacts with Host Cytokeratin 19 To Promote Colonization of the Female Reproductive Tract. Manzer HS, Nguyen DT, Park JY, Park N, Seo KS, Thornton JA, Nobbs AH, Doran KS. mBio 13 e0178122 (2022)
  14. The Streptococcus agalactiae complement interfering protein combines multiple complement-inhibitory mechanisms by interacting with both C4 and C3 ligands. Giussani S, Pietrocola G, Donnarumma D, Norais N, Speziale P, Fabbrini M, Margarit I. FASEB J. 33 4448-4457 (2019)
  15. The streptococcal multidomain fibrillar adhesin CshA has an elongated polymeric architecture. Back CR, Higman VA, Le Vay K, Patel VV, Parnell AE, Frankel D, Jenkinson HF, Burston SG, Crump MP, Nobbs AH, Race PR. J Biol Chem 295 6689-6699 (2020)


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