› 5e0r

X-ray diffraction
1.35Å resolution

Crystal Structure of the first bromodomain of BRD4 in complex with AYC

Released:
DOI: 10.2210/pdb5e0r/pdb
PDB entry 5e0r coloured by chain, front view.
PDB entry 5e0r coloured by chain, side view.
PDB entry 5e0r coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dong J, Caflisch A

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130112 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 15.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O60885 (Residues: 44-168; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

2 bound ligands:
Ligand 5J5 5 x 5J5
Ligand DMS 1 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 36.776Å b: 44.538Å c: 77.964Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.171 0.198
Expression system: Escherichia coli BL21(DE3)

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