5ebk

X-ray diffraction
3.51Å resolution

Trypanothione reductase in complex with 6-(sec-butoxy)-2-((3-chlorophenyl)thio)pyrimidin-4-amine

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
PDBe Complex ID:
PDB-CPX-107319 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Trypanothione reductase Chains: A, B
Molecule details ›
Chains: A, B
Length: 511 amino acids
Theoretical weight: 55.26 KDa
Source organism: Leishmania infantum
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A4HSF7 (Residues: 1-491; Coverage: 100%)
Gene names: LINJ_05_0350, TRYR
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand FAD 2 x FAD
2 bound ligands:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P41
Unit cell:
a: 102.5Å b: 102.5Å c: 192Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.208 0.233
Expression system: Escherichia coli BL21(DE3)