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Crystal structure of the BRCT domains of 53BP1 in complex with p53 and H2AX-pSer139 (gammaH2AX)

Source organism: Homo sapiens
Biochemical function: DNA-binding transcription factor activity
Biological process: apoptotic process
Cellular component: nucleus

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF18428
Domain description: BRCA1 C Terminus (BRCT) domain
Occurring in:
  1. TP53-binding protein 1
The deposited structure of PDB entry 5ecg contains 2 copies of Pfam domain PF18428 (BRCA1 C Terminus (BRCT) domain) in TP53-binding protein 1. Showing 1 copy in chain C.

PF00870
Domain description: P53 DNA-binding domain
Occurring in:
  1. Cellular tumor antigen p53
The deposited structure of PDB entry 5ecg contains 2 copies of Pfam domain PF00870 (P53 DNA-binding domain) in Cellular tumor antigen p53. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002117
Domain description: p53 tumour suppressor family
Occurring in:
  1. Cellular tumor antigen p53
IPR001357
Domain description: BRCT domain
Occurring in:
  1. TP53-binding protein 1
IPR036420
Domain description: BRCT domain superfamily
Occurring in:
  1. TP53-binding protein 1
IPR011615
Domain description: p53, DNA-binding domain
Occurring in:
  1. Cellular tumor antigen p53
IPR047250
Domain description: TP53-binding protein 1-like, second BRCT domain
Occurring in:
  1. TP53-binding protein 1
IPR047249
Domain description: TP53-binding protein 1-like, first BRCT domain
Occurring in:
  1. TP53-binding protein 1
IPR047252
Domain description: TP53-binding protein 1-like
Occurring in:
  1. TP53-binding protein 1
IPR008967
Domain description: p53-like transcription factor, DNA-binding domain superfamily
Occurring in:
  1. Cellular tumor antigen p53
IPR012346
Domain description: p53/RUNT-type transcription factor, DNA-binding domain superfamily
Occurring in:
  1. Cellular tumor antigen p53

Structure domains

CATH CATH domains
3.40.50.10190
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: BRCT domain
Occurring in:
  1. TP53-binding protein 1
The deposited structure of PDB entry 5ecg contains 4 copies of CATH domain 3.40.50.10190 (Rossmann fold) in TP53-binding protein 1. Showing 2 copies in chain C.
2.60.40.720
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulin-like
Occurring in:
  1. Cellular tumor antigen p53
The deposited structure of PDB entry 5ecg contains 2 copies of CATH domain 2.60.40.720 (Immunoglobulin-like) in Cellular tumor antigen p53. Showing 1 copy in chain A.

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