EC 4.4.1.2: Homocysteine desulfhydrase
Reaction catalysed:
(1a) L-homocysteine = hydrogen sulfide + 2-aminobut-2-enoate
Systematic name:
L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming)
Alternative Name(s):
- Homocysteine desulfurase
- L-homocysteine hydrogen-sulfide-lyase (deaminating)
EC 4.4.1.1: Cystathionine gamma-lyase
Reaction catalysed:
(1a) L-cystathionine = L-cysteine + 2-aminobut-2-enoate
Systematic name:
L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)
Alternative Name(s):
- Cystalysin
- Cystathionase
- Cystathioninase
- Cysteine desulfhydrase
- Cysteine lyase
- Cystine desulfhydrase
- Gamma-CTL
- Gamma-cystathionase
- Homoserine deaminase
- Homoserine deaminase-cystathionase
- Homoserine dehydratase
- L-cystathionine cysteine-lyase (deaminating)
GO terms
Biochemical function:
Biological process:
- negative regulation of apoptotic signaling pathway
- cellular response to leukemia inhibitory factor
- positive regulation of aortic smooth muscle cell differentiation
- hydrogen sulfide biosynthetic process
- protein homotetramerization
- protein sulfhydration
- positive regulation of canonical NF-kappaB signal transduction
- negative regulation of apoptotic process
- endoplasmic reticulum unfolded protein response
- transsulfuration
- cysteine biosynthetic process
- cysteine biosynthetic process via cystathionine
- protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
- lipid metabolic process
- cysteine metabolic process
Cellular component:
Sequence family
Protein family (Pfam)
InterPro annotations
IPR000277
Domain description:
Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
Occurring in:
Occurring in:
Structure domains
CATH domains
3.90.1150.10
Class:
Alpha Beta
Architecture:
Alpha-Beta Complex
Topology:
Aspartate Aminotransferase, domain 1
Homology:
Aspartate Aminotransferase, domain 1
Occurring in:
