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Crystal structural of the TSC1-TBC1D7 complex

X-ray diffraction
3.1Å resolution
PDB entry 5ejc coloured by chain, front view.
PDB entry 5ejc coloured by chain, side view.
PDB entry 5ejc coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hamartin and TBC1 domain family member 7
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Multimeric state: hetero trimer
Accessible surface area: 17239.16 Å2
Buried surface area: 4039.65 Å2
Dissociation area: 1,067.3 Å2
Dissociation energy (ΔGdiss): 3.14 kcal/mol
Dissociation entropy (TΔSdiss): 10.99 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-187694
Assembly 2
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Assembly Name: Hamartin and TBC1 domain family member 7
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Multimeric state: hetero trimer
Accessible surface area: 16474.9 Å2
Buried surface area: 3921.37 Å2
Dissociation area: 1,052.27 Å2
Dissociation energy (ΔGdiss): 3.4 kcal/mol
Dissociation entropy (TΔSdiss): 10.78 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-187694

Macromolecules

TBC1 domain family member 7
Chains: A, B
Length: 276 amino acids
Theoretical weight: 32.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9P0N9 (Residues: 18-293; Coverage: 94%)
Gene names: HSPC239, TBC1D7, TBC7
Pfam: Rab-GTPase-TBC domain
InterPro:
CATH:
TBC1 domain family member 7 in PDB entry 5ejc, assembly 1, front view.
TBC1 domain family member 7 in PDB entry 5ejc, assembly 1, side view.
TBC1 domain family member 7 in PDB entry 5ejc, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q9P0N9  
127620406080100120140160180200220240260
 
100200GFRGVEEKKSLEILLKDDRLDTEKLCTFSQRFPLPS*YRALVWKVLLGILPPHHESHAKV**YRKEQYLDVLHALKVVRFVSDATPQAEVYLR*YQLESGKLPRSPSFPLEPDDEVFLAIAKA*EE*VEDSVDCYWITRRFVNQLNTKYRDSLPQLPKAFEQYLNLEDGRLLTHLR*CSAAPKLPYDLWFKRCFAGCLPESSLQRVWDKVVSGSCKILVFVAVEILLTFKIKV*ALNSAEKITKFLENIPQDSSDAIVSKAIDLWHKHCGTPVHSS
UniProt
Q9P0N9
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Interaction interfaces
Sequence conservation
Variants
Molecule details ›

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Hamartin
Chains: C, D, E, F
Length: 55 amino acids
Theoretical weight: 6.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92574 (Residues: 939-992; Coverage: 5%)
Gene names: KIAA0243, TSC, TSC1
Hamartin in PDB entry 5ejc, assembly 1, front view.
Hamartin in PDB entry 5ejc, assembly 1, side view.
Hamartin in PDB entry 5ejc, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q92574  
155510152025303540455055
 
2040GGQLQAAESRYEAQKRITQVFELEILDLYGRLEKDGLLKKLEEEKAEAAEAAEER
UniProt
Q92574
Chains
Secondary structure
Flexibility predictions
Early folding residue predictions
Interaction interfaces
Sequence conservation
Molecule details ›

Search similar proteins

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