› 5emg

X-ray diffraction
1.06Å resolution

Crystal structures of PNA p(GCTGCTGC)2 duplex containing T-T mismatches

Released:
DOI: 10.2210/pdb5emg/pdb
PDB entry 5emg coloured by chain, front view.
PDB entry 5emg coloured by chain, side view.
PDB entry 5emg coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
The first crystal structures of RNA-PNA duplexes and a PNA-PNA duplex containing mismatches--toward anti-sense therapy against TREDs.
Kiliszek A, Banaszak K, Dauter Z, Rypniewski W
OpenAccess logo Nucleic Acids Res 44 1937-43 (2016)
PMID: 26717983

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-165607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GPN-CPN-TPN-GPN-CPN-TPN-GPN-CPN Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 8 amino acids
Theoretical weight: 2.19 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand CL 12 x CL
Ligand NA 6 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P212121
Unit cell:
a: 28.771Å b: 42.896Å c: 64.253Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.164 0.163 0.193
Expression system: Not provided

Quick links

Citations

3 review citations

Peptide nucleic acids: Advanced tools for biomedical applications.
Gupta et al. (2017)
2 more

3 mentions without citation

Antibacterial Peptide Nucleic Acids-Facts and Perspectives.
Wojciechowska et al. (2020)
2 more