Function and Biology

Human GLUT1 in complex with inhibitor (2~{S})-3-(4-fluorophenyl)-2-[2-(3-hydroxyphenyl)ethanoylamino]-~{N}-[(1~{S})-1-phenylethyl]propanamide

Source organism: Homo sapiens

Sequence family

Pfam Protein family (Pfam)
PF00083
Domain description: Sugar (and other) transporter
Occurring in:
  1. Solute carrier family 2, facilitated glucose transporter member 1
The deposited structure of PDB entry 5eqg contains 1 copy of Pfam domain PF00083 (Sugar (and other) transporter) in Solute carrier family 2, facilitated glucose transporter member 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003663
Domain description: Sugar/inositol transporter
Occurring in:
  1. Solute carrier family 2, facilitated glucose transporter member 1
IPR002439
Domain description: Glucose transporter, type 1 (GLUT1)
Occurring in:
  1. Solute carrier family 2, facilitated glucose transporter member 1
IPR005829
Domain description: Sugar transporter, conserved site
Occurring in:
  1. Solute carrier family 2, facilitated glucose transporter member 1
IPR036259
Domain description: MFS transporter superfamily
Occurring in:
  1. Solute carrier family 2, facilitated glucose transporter member 1
IPR005828
Domain description: Major facilitator, sugar transporter-like
Occurring in:
  1. Solute carrier family 2, facilitated glucose transporter member 1
IPR020846
Domain description: Major facilitator superfamily domain
Occurring in:
  1. Solute carrier family 2, facilitated glucose transporter member 1
IPR045263
Domain description: Glucose transporter GLUT
Occurring in:
  1. Solute carrier family 2, facilitated glucose transporter member 1

Structure domain

CATH CATH domain
1.20.1250.20
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Growth Hormone; Chain: A;
Homology: MFS general substrate transporter like domains
Occurring in:
  1. Solute carrier family 2, facilitated glucose transporter member 1
The deposited structure of PDB entry 5eqg contains 1 copy of CATH domain 1.20.1250.20 (Growth Hormone; Chain: A;) in Solute carrier family 2, facilitated glucose transporter member 1. Showing 1 copy in chain A.