› 5esn

X-ray diffraction
2.35Å resolution

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) T322I mutant structure

Released:
DOI: 10.2210/pdb5esn/pdb
PDB entry 5esn coloured by chain, front view.
PDB entry 5esn coloured by chain, side view.
PDB entry 5esn coloured by chain, top view.
Source organism: Saccharomyces cerevisiae YJM789
Entry authors: Sagatova A, Keniya MV, Wilson RK, Sabherwal M, Tyndall JDA, Monk BC

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-501092 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lanosterol 14-alpha demethylase Chain: A
Molecule details ›
Chain: A
Length: 539 amino acids
Theoretical weight: 61.9 KDa
Source organism: Saccharomyces cerevisiae YJM789
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: A6ZSR0 (Residues: 1-530; Coverage: 100%)
Gene names: ERG11, SCY_2394
Sequence domains: Cytochrome P450

Ligands and Environments


Cofactor: Ligand HEM 1 x HEM
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 77.52Å b: 65.95Å c: 80.95Å
α: 90° β: 98.84° γ: 90°
R-values:
R R work R free
0.186 0.184 0.228
Expression system: Saccharomyces cerevisiae

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