› 5ezp

X-ray diffraction
2.5Å resolution

Human transthyretin (TTR) complexed with 4-hydroxy-chalcone

Released:
DOI: 10.2210/pdb5ezp/pdb
PDB entry 5ezp coloured by chain, front view.
PDB entry 5ezp coloured by chain, side view.
PDB entry 5ezp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A new crystal form of human transthyretin obtained with a curcumin derived ligand.
Polsinelli I, Nencetti S, Shepard W, Ciccone L, Orlandini E, Stura EA
J Struct Biol 194 8-17 (2016)
PMID: 26796656

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 122 amino acids
Theoretical weight: 13.36 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02766 (Residues: 26-147; Coverage: 96%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

2 bound ligands:
Ligand IPJ 5 x IPJ
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: P31
Unit cell:
a: 62.48Å b: 62.48Å c: 238.32Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.212 0.21 0.245

Quick links

Citations

4 review citations

Uncovering the Neuroprotective Mechanisms of Curcumin on Transthyretin Amyloidosis.
Ferreira et al. (2019)
3 more

3 mentions without citation

Natural compounds as inhibitors of transthyretin amyloidosis and neuroprotective agents: analysis of structural data for future drug design.
Ciccone et al. (2020)
2 more