› 5ezu

X-ray diffraction
1.55Å resolution

Crystal structure of the N-terminal domain of vaccinia virus immunomodulator A46 in complex with myristic acid.

Released:
DOI: 10.2210/pdb5ezu/pdb
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PDB entry 5ezu coloured by chain, front view.
PDB entry 5ezu coloured by chain, side view.
PDB entry 5ezu coloured by chain, top view.
Source organism: Vaccinia virus WR
Primary publication:
Vaccinia Virus Immunomodulator A46: A Lipid and Protein-Binding Scaffold for Sequestering Host TIR-Domain Proteins.
Fedosyuk S, Bezerra GA, Radakovics K, Smith TK, Sammito M, Bobik N, Round A, Ten Eyck LF, Djinović-Carugo K, Usón I, Skern T
OpenAccess logo PLoS Pathog 12 e1006079 (2016)
PMID: 27973613

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150826 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein OPG176 Chains: A, B
Molecule details ›
Chains: A, B
Length: 89 amino acids
Theoretical weight: 10.04 KDa
Source organism: Vaccinia virus WR
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P26672 (Residues: 1-83; Coverage: 35%)
Gene names: A46R, OPG176, VACWR172
Sequence domains: Poxvirus Bcl-2-like proteins

Ligands and Environments

1 bound ligand:
Ligand MYR 1 x MYR
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: C2
Unit cell:
a: 65.787Å b: 59.58Å c: 47.257Å
α: 90° β: 117.7° γ: 90°
R-values:
R R work R free
0.202 0.2 0.242
Expression system: Escherichia coli BL21(DE3)

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Citations

6 review citations

The Bcl-2 Family in Host-Virus Interactions.
Kvansakul et al. (2017)
5 more

3 mentions without citation

ALEPH: a network-oriented approach for the generation of fragment-based libraries and for structure interpretation.
Medina et al. (2020)
2 more

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