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Murine endoplasmic reticulum alpha-glucosidase II

X-ray diffraction
1.74Å resolution
PDB entry 5f0e coloured by chain, front view.
PDB entry 5f0e coloured by chain, side view.
PDB entry 5f0e coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glucosidase 2 subunit beta and Neutral alpha-glucosidase AB
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Multimeric state: hetero dimer
Accessible surface area: 34654.91 Å2
Buried surface area: 6647.5 Å2
Dissociation area: 1,008.81 Å2
Dissociation energy (ΔGdiss): -15.46 kcal/mol
Dissociation entropy (TΔSdiss): 12.22 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126675

Macromolecules

Neutral alpha-glucosidase AB
Chain: A
Length: 857 amino acids
Theoretical weight: 97.89 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8BHN3 (Residues: 33-944; Coverage: 94%)
  • Best match: Q8BHN3-3 (Residues: 1-692)
Gene names: G2an, Ganab, Kiaa0088
Pfam:
InterPro:
Neutral alpha-glucosidase AB in PDB entry 5f0e, assembly 1, front view.
Neutral alpha-glucosidase AB in PDB entry 5f0e, assembly 1, side view.
Neutral alpha-glucosidase AB in PDB entry 5f0e, assembly 1, top view.
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Glucosidase 2 subunit beta
Chain: B
Length: 88 amino acids
Theoretical weight: 9.57 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: O08795 (Residues: 30-117; Coverage: 17%)
Gene name: Prkcsh
Pfam: Glucosidase II beta subunit-like
InterPro:
Glucosidase 2 subunit beta in PDB entry 5f0e, assembly 1, front view.
Glucosidase 2 subunit beta in PDB entry 5f0e, assembly 1, side view.
Glucosidase 2 subunit beta in PDB entry 5f0e, assembly 1, top view.
Molecule details ›

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