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Structure of myostatin in complex with chimeric RK35 antibody

Source organisms:
Biochemical function: growth factor activity
Biological process: not assigned
Cellular component: extracellular region

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GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00019
Domain description: Transforming growth factor beta like domain
Occurring in:
  1. Growth/differentiation factor 8
The deposited structure of PDB entry 5f3b contains 2 copies of Pfam domain PF00019 (Transforming growth factor beta like domain) in Growth/differentiation factor 8. Showing 1 copy in chain E [auth C].

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. RK35 Chimeric antibody heavy chain
  2. RK35 Chimeric antibody light chain
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. RK35 Chimeric antibody heavy chain
  2. RK35 Chimeric antibody light chain
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. RK35 Chimeric antibody heavy chain
  2. RK35 Chimeric antibody light chain
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. RK35 Chimeric antibody heavy chain
  2. RK35 Chimeric antibody light chain
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. RK35 Chimeric antibody heavy chain
  2. RK35 Chimeric antibody light chain
IPR001839
Domain description: Transforming growth factor-beta, C-terminal
Occurring in:
  1. Growth/differentiation factor 8
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. RK35 Chimeric antibody heavy chain
  2. RK35 Chimeric antibody light chain
IPR029034
Domain description: Cystine-knot cytokine
Occurring in:
  1. Growth/differentiation factor 8
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. RK35 Chimeric antibody heavy chain
  2. RK35 Chimeric antibody light chain
IPR017948
Domain description: Transforming growth factor beta, conserved site
Occurring in:
  1. Growth/differentiation factor 8
IPR015615
Domain description: Transforming growth factor-beta-related
Occurring in:
  1. Growth/differentiation factor 8

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. RK35 Chimeric antibody heavy chain
  2. RK35 Chimeric antibody light chain
The deposited structure of PDB entry 5f3b contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in RK35 Chimeric antibody heavy chain. Showing 2 copies in chain A.
The deposited structure of PDB entry 5f3b contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in RK35 Chimeric antibody light chain. Showing 2 copies in chain B.
2.10.90.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Cystine Knot Cytokines, subunit B
Homology: Cystine-knot cytokines
Occurring in:
  1. Growth/differentiation factor 8
The deposited structure of PDB entry 5f3b contains 2 copies of CATH domain 2.10.90.10 (Cystine Knot Cytokines, subunit B) in Growth/differentiation factor 8. Showing 1 copy in chain E [auth C].

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