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Y208F mutant of choline TMA-lyase

Source organism: Oleidesulfovibrio alaskensis G20
Biochemical function: choline trimethylamine lyase activity
Biological process: choline catabolic process
Cellular component: cytosol

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EC 4.3.99.4: Choline trimethylamine-lyase

Reaction catalysed:
Choline = trimethylamine + acetaldehyde
Systematic name:
Choline trimethylamine-lyase (acetaldehyde-forming)
Alternative Name(s):
  • CutC (gene name)

GO terms

Sequence families

Pfam Protein families (Pfam)
PF01228
Domain description: Glycine radical
Occurring in:
  1. Choline trimethylamine-lyase
The deposited structure of PDB entry 5fay contains 2 copies of Pfam domain PF01228 (Glycine radical) in Choline trimethylamine-lyase. Showing 1 copy in chain A.

PF02901
Domain description: Pyruvate formate lyase-like
Occurring in:
  1. Choline trimethylamine-lyase
The deposited structure of PDB entry 5fay contains 2 copies of Pfam domain PF02901 (Pyruvate formate lyase-like) in Choline trimethylamine-lyase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001150
Domain description: Glycine radical domain
Occurring in:
  1. Choline trimethylamine-lyase
IPR004184
Domain description: Pyruvate formate lyase domain
Occurring in:
  1. Choline trimethylamine-lyase
IPR030897
Domain description: Choline trimethylamine-lyase
Occurring in:
  1. Choline trimethylamine-lyase
IPR019777
Domain description: Formate C-acetyltransferase glycine radical, conserved site
Occurring in:
  1. Choline trimethylamine-lyase

Structure domain

CATH CATH domain
3.20.70.20
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: Anaerobic Ribonucleotide-triphosphate Reductase Large Chain
Homology: Anaerobic Ribonucleotide-triphosphate Reductase Large Chain
Occurring in:
  1. Choline trimethylamine-lyase
The deposited structure of PDB entry 5fay contains 2 copies of CATH domain 3.20.70.20 (Anaerobic Ribonucleotide-triphosphate Reductase Large Chain) in Choline trimethylamine-lyase. Showing 1 copy in chain A.

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