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CRYSTAL STRUCTURE OF FUNGAL VERSATILE PEROXIDASE FROM PLEUROTUS ERYNGII TRIPLE MUTANT E37K, H39R & G330R

Source organism: Pleurotus eryngii
Biochemical function: reactive-black-5:hydrogen-peroxide oxidoreductase activity
Biological process: cellular oxidant detoxification
Cellular component: extracellular region

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EC 1.11.1.16: Versatile peroxidase

Reaction catalysed:
1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H(2)O(2) = 4-hydroxy-3-methoxybenzaldehyde + 2-methoxyphenol + glycolaldehyde + H(2)O
Systematic name:
1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol:hydrogen-peroxide oxidoreductase
Alternative Name(s):
  • Hybrid peroxidase
  • Polyvalent peroxidase
  • Reactive-black-5:hydrogen-peroxide oxidoreductase
  • VP

GO terms

Sequence families

Pfam Protein families (Pfam)
PF11895
Domain description: Fungal peroxidase extension region
Occurring in:
  1. Versatile peroxidase VPL2
The deposited structure of PDB entry 5fne contains 1 copy of Pfam domain PF11895 (Fungal peroxidase extension region) in Versatile peroxidase VPL2. Showing 1 copy in chain A.

PF00141
Domain description: Peroxidase
Occurring in:
  1. Versatile peroxidase VPL2
The deposited structure of PDB entry 5fne contains 1 copy of Pfam domain PF00141 (Peroxidase) in Versatile peroxidase VPL2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001621
Domain description: Fungal ligninase
Occurring in:
  1. Versatile peroxidase VPL2
IPR002016
Domain description: Haem peroxidase
Occurring in:
  1. Versatile peroxidase VPL2
IPR024589
Domain description: Fungal ligninase, C-terminal
Occurring in:
  1. Versatile peroxidase VPL2
IPR019793
Domain description: Peroxidases heam-ligand binding site
Occurring in:
  1. Versatile peroxidase VPL2
IPR019794
Domain description: Peroxidase, active site
Occurring in:
  1. Versatile peroxidase VPL2
IPR044831
Domain description: Heme-binding peroxidase Ccp1-like
Occurring in:
  1. Versatile peroxidase VPL2
IPR010255
Domain description: Haem peroxidase superfamily
Occurring in:
  1. Versatile peroxidase VPL2

Structure domains

CATH CATH domains
1.10.420.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Peroxidase; domain 2
Homology: Peroxidase, domain 2
Occurring in:
  1. Versatile peroxidase VPL2
The deposited structure of PDB entry 5fne contains 1 copy of CATH domain 1.10.420.10 (Peroxidase; domain 2) in Versatile peroxidase VPL2. Showing 1 copy in chain A.
1.10.520.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Peroxidase; domain 1
Homology: Peroxidase; domain 1
Occurring in:
  1. Versatile peroxidase VPL2
The deposited structure of PDB entry 5fne contains 1 copy of CATH domain 1.10.520.10 (Peroxidase; domain 1) in Versatile peroxidase VPL2. Showing 1 copy in chain A.

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