› 5ftt

X-ray diffraction
3.4Å resolution

Octameric complex of Latrophilin 3 (Lec, Olf) , Unc5D (Ig, Ig2, TSP1) and FLRT2 (LRR)

Released:
DOI: 10.2210/pdb5ftt/pdb
PDB entry 5ftt coloured by chain, front view.
PDB entry 5ftt coloured by chain, side view.
PDB entry 5ftt coloured by chain, top view.
Source organisms:
Primary publication:
Super-complexes of adhesion GPCRs and neural guidance receptors.
Jackson VA, Mehmood S, Chavent M, Roversi P, Carrasquero M, Del Toro D, Seyit-Bremer G, Ranaivoson FM, Comoletti D, Sansom MS, Robinson CV, Klein R, Seiradake E
OpenAccess logo Nat Commun 7 11184 (2016)
PMID: 27091502

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-123308 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Netrin receptor UNC5D Chains: A, E
Molecule details ›
Chains: A, E
Length: 285 amino acids
Theoretical weight: 31.94 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: F1LW30 (Residues: 32-307; Coverage: 30%)
Gene name: Unc5d
Sequence domains:
Leucine-rich repeat transmembrane protein FLRT2 Chains: B, F
Molecule details ›
Chains: B, F
Length: 339 amino acids
Theoretical weight: 38.41 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8BLU0 (Residues: 35-362; Coverage: 52%)
Gene names: Flrt2, Kiaa0405
Sequence domains:
Structure domains: Ribonuclease Inhibitor
Adhesion G protein-coupled receptor L3 Chains: C, D, G, H
Molecule details ›
Chains: C, D, G, H
Length: 383 amino acids
Theoretical weight: 43.91 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q80TS3 (Residues: 92-463; Coverage: 25%)
Gene names: Adgrl3, Kiaa0768, Lec3, Lphn3
Sequence domains:
Structure domains: Jelly Rolls

Ligands and Environments

3 bound ligands:
Ligand NAG 8 x NAG
Ligand NA 4 x NA
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2
Unit cell:
a: 231.961Å b: 141.486Å c: 151.491Å
α: 90° β: 117.94° γ: 90°
R-values:
R R work R free
0.226 0.225 0.245
Expression system: Homo sapiens

Quick links

Citations

18 review citations

Adhesion G Protein-Coupled Receptors as Drug Targets.
Purcell et al. (2018)
17 more

7 mentions without citation

Towards an Understanding of Synapse Formation.
Südhof TC. (2018)
6 more