› 5ful

X-ray diffraction
1.89Å resolution

Crystal Structure of Mus musculus Protein Arginine Methyltransferase 2 with SAH

Released:
DOI: 10.2210/pdb5ful/pdb
PDB entry 5ful coloured by chain, front view.
PDB entry 5ful coloured by chain, side view.
PDB entry 5ful coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors.
Cura V, Marechal N, Troffer-Charlier N, Strub JM, van Haren MJ, Martin NI, Cianférani S, Bonnefond L, Cavarelli J
FEBS J 284 77-96 (2017)
PMID: 27879050

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-559194 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SH3 domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 446 amino acids
Theoretical weight: 50.64 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q3UKX1 (Residues: 1-445; Coverage: 100%)
Gene names: Hrmt1l1, Prmt2
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand SAH 1 x SAH
4 bound ligands:
Ligand CA 2 x CA
Ligand PG4 1 x PG4
Ligand CL 1 x CL
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: C2221
Unit cell:
a: 65.507Å b: 115.414Å c: 132.963Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.167 0.166 0.192
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

Protein arginine methyltransferases: insights into the enzyme structure and mechanism at the atomic level.
Tewary et al. (2019)
4 more

5 mentions without citation

Structure, Activity and Function of the PRMT2 Protein Arginine Methyltransferase.
Cura et al. (2021)
4 more