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Structure of Bacillus subtilis Nitric Oxide Synthase in complex with 7-((3-Fluorophenethylamino)ethyl)quinolin-2-amine

Source organism: Bacillus subtilis subsp. subtilis str. 168
Biochemical function: metal ion binding
Biological process: nitric oxide biosynthetic process
Cellular component: not assigned

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EC 1.14.14.47: Nitric-oxide synthase (flavodoxin)

Reaction catalysed:
(1a) 2 L-arginine + 2 reduced flavodoxin + 2 O(2) = 2 N(omega)-hydroxy-L-arginine + 2 oxidized flavodoxin + 2 H(2)O
Systematic name:
L-arginine,reduced-flavodoxin:oxygen oxidoreductase (nitric-oxide-forming)
Alternative Name(s):
  • NO synthase
  • Nitric oxide synthetase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF02898
Domain description: Nitric oxide synthase, oxygenase domain
Occurring in:
  1. Nitric oxide synthase oxygenase
The deposited structure of PDB entry 5g6a contains 1 copy of Pfam domain PF02898 (Nitric oxide synthase, oxygenase domain) in Nitric oxide synthase oxygenase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004030
Domain description: Nitric oxide synthase, N-terminal
Occurring in:
  1. Nitric oxide synthase oxygenase
IPR044944
Domain description: Nitric oxide synthase, domain 3 superfamily
Occurring in:
  1. Nitric oxide synthase oxygenase
IPR044940
Domain description: Nitric oxide synthase, domain 2 superfamily
Occurring in:
  1. Nitric oxide synthase oxygenase
IPR044943
Domain description: Nitric oxide synthase, domain 1 superfamily
Occurring in:
  1. Nitric oxide synthase oxygenase
IPR036119
Domain description: Nitric oxide synthase, N-terminal domain superfamily
Occurring in:
  1. Nitric oxide synthase oxygenase
IPR017142
Domain description: Nitric oxide synthase, oxygenase subunit
Occurring in:
  1. Nitric oxide synthase oxygenase

Structure domains

CATH CATH domains
3.90.340.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Nitric Oxide Synthase; Chain A, domain 1
Homology: Nitric Oxide Synthase; Chain A, domain 1
Occurring in:
  1. Nitric oxide synthase oxygenase
The deposited structure of PDB entry 5g6a contains 1 copy of CATH domain 3.90.340.10 (Nitric Oxide Synthase; Chain A, domain 1) in Nitric oxide synthase oxygenase. Showing 1 copy in chain A.
3.90.440.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Nitric Oxide Synthase;Heme Domain; Chain A, domain 2
Homology: Nitric Oxide Synthase;Heme Domain;Chain A domain 2
Occurring in:
  1. Nitric oxide synthase oxygenase
The deposited structure of PDB entry 5g6a contains 1 copy of CATH domain 3.90.440.10 (Nitric Oxide Synthase;Heme Domain; Chain A, domain 2) in Nitric oxide synthase oxygenase. Showing 1 copy in chain A.
3.90.1230.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Bovine Endothelial Nitric Oxide Synthase Heme Domain; Chain: A,domain 3
Homology: Nitric Oxide Synthase; Chain A, domain 3
Occurring in:
  1. Nitric oxide synthase oxygenase
The deposited structure of PDB entry 5g6a contains 1 copy of CATH domain 3.90.1230.10 (Bovine Endothelial Nitric Oxide Synthase Heme Domain; Chain: A,domain 3) in Nitric oxide synthase oxygenase. Showing 1 copy in chain A.

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