› 5giw

Solution NMR

Solution NMR structure of Humanin containing a D-isomerized serine residue

Released:
DOI: 10.2210/pdb5giw/pdb
PDB entry 5giw coloured by chain, ensemble of 20 models, front view.
PDB entry 5giw coloured by chain, ensemble of 20 models, side view.
PDB entry 5giw coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution NMR structure and inhibitory effect against amyloid-β fibrillation of Humanin containing a d-isomerized serine residue.
Alsanousi N, Sugiki T, Furuita K, So M, Lee YH, Fujiwara T, Kojima C
Biochem Biophys Res Commun 477 647-653 (2016)
PMID: 27349871

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184868 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Humanin Chain: X
Molecule details ›
Chain: X
Length: 24 amino acids
Theoretical weight: 2.69 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q8IVG9 (Residues: 1-24; Coverage: 100%)
Gene names: HN, MT-RNR2
Sequence domains: Humanin family

Ligands and Environments

No bound ligands
1 modified residue:
Ligand DSN 1 x DSN

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 57%
Refinement method: simulated annealing
Expression system: Not provided

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Citations

4 review citations

In Search of Lost Small Peptides.
Plaza et al. (2017)
3 more