› 5gpn

Electron Microscopy
5.4Å resolution

Architecture of mammalian respirasome

Released:
DOI: 10.2210/pdb5gpn/pdb
PDB entry 5gpn coloured by chain, front view.
PDB entry 5gpn coloured by chain, side view.
PDB entry 5gpn coloured by chain, top view.
Source organisms:
Primary publication:
The architecture of the mammalian respirasome.
Gu J, Wu M, Guo R, Yan K, Lei J, Gao N, Yang M
Nature 537 639-43 (2016)
PMID: 27654917
Related structures: EMD-9534

Function and Biology Details

Reactions catalysed: 
Quinol + 2 ferricytochrome c(Side 2) = quinone + 2 ferrocytochrome c(Side 2) + 2 H(+)(Side 2)
NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)
4 ferrocytochrome c + O(2) + 8 H(+)(Side 1) = 4 ferricytochrome c + 4 H(2)O(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 84-mer (preferred)
PDBe Complex ID:
PDB-CPX-236796 (preferred)
Entry contents:
63 distinct polypeptide molecules
Macromolecules (63 distinct):
Cytochrome b-c1 complex subunit 1, mitochondrial Chains: A, M
Molecule details ›
Chains: A, M
Length: 446 amino acids
Theoretical weight: 49.27 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P31800 (Residues: 35-480; Coverage: 93%)
Gene name: UQCRC1
Sequence domains:
Cytochrome b-c1 complex subunit 2, mitochondrial Chains: B, N
Molecule details ›
Chains: B, N
Length: 439 amino acids
Theoretical weight: 46.58 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P23004 (Residues: 15-453; Coverage: 97%)
Gene name: UQCRC2
Sequence domains:
Cytochrome b Chains: C, O
Molecule details ›
Chains: C, O
Length: 379 amino acids
Theoretical weight: 42.62 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00157 (Residues: 1-379; Coverage: 100%)
Gene names: COB, CYTB, MT-CYB, MTCYB
Sequence domains:
Cytochrome c1, heme protein, mitochondrial Chains: D, P
Molecule details ›
Chains: D, P
Length: 241 amino acids
Theoretical weight: 27.32 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00125 (Residues: 85-325; Coverage: 74%)
Gene name: CYC1
Sequence domains: Cytochrome C1 family
Cytochrome b-c1 complex subunit Rieske, mitochondrial Chains: E, Q
Molecule details ›
Chains: E, Q
Length: 274 amino acids
Theoretical weight: 29.57 KDa
Source organism: Bos taurus
Cytochrome b-c1 complex subunit 7 Chains: F, R
Molecule details ›
Chains: F, R
Length: 110 amino acids
Theoretical weight: 13.37 KDa
Source organism: Bos taurus
Cytochrome b-c1 complex subunit 8 Chains: G, S
Molecule details ›
Chains: G, S
Length: 81 amino acids
Theoretical weight: 9.61 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P13271 (Residues: 2-82; Coverage: 99%)
Gene name: UQCRQ
Sequence domains: UcrQ family
Cytochrome b-c1 complex subunit 6, mitochondrial Chains: H, T
Molecule details ›
Chains: H, T
Length: 78 amino acids
Theoretical weight: 9.19 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00126 (Residues: 14-91; Coverage: 86%)
Gene name: UQCRH
Sequence domains: Ubiquinol-cytochrome C reductase hinge protein
Cytochrome b-c1 complex subunit 9 Chains: I, U
Molecule details ›
Chains: I, U
Length: 78 amino acids
Theoretical weight: 7.96 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P13272 (Residues: 1-78; Coverage: 29%)
Gene name: UQCRFS1
Sequence domains: Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
Cytochrome b-c1 complex subunit 9 Chains: J, L
Molecule details ›
Chains: J, L
Length: 62 amino acids
Theoretical weight: 7.21 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00130 (Residues: 2-63; Coverage: 97%)
Gene name: UQCR10
Sequence domains: Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like
Cytochrome b-c1 complex subunit 10 Chains: K, V
Molecule details ›
Chains: K, V
Length: 56 amino acids
Theoretical weight: 6.53 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P07552 (Residues: 1-56; Coverage: 100%)
Gene names: UQCR, UQCR11
Sequence domains: Ubiquinol-cytochrome C reductase complex, 6.4kD protein
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3 Chain: W
Molecule details ›
Chain: W
Length: 264 amino acids
Theoretical weight: 30.24 KDa
Source organism: Sus scrofa
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial Chain: Y
Molecule details ›
Chain: Y
Length: 727 amino acids
Theoretical weight: 79.63 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1V1H9 (Residues: 1-727; Coverage: 100%)
Gene name: NDUFS1
Sequence domains:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial Chain: Z
Molecule details ›
Chain: Z
Length: 463 amino acids
Theoretical weight: 52.55 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1S1A8 (Residues: 7-469; Coverage: 100%)
Gene name: NDUFS2
Sequence domains: Respiratory-chain NADH dehydrogenase, 49 Kd subunit
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial Chain: a
Molecule details ›
Chain: a
Length: 216 amino acids
Theoretical weight: 23.78 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D1TL60 (Residues: 1-21, 22-196; Coverage: 100%)
Gene name: NDUFS7
Sequence domains: NADH ubiquinone oxidoreductase, 20 Kd subunit
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8 Chain: b
Molecule details ›
Chain: b
Length: 212 amino acids
Theoretical weight: 23.89 KDa
Source organism: Sus scrofa
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial Chain: c
Molecule details ›
Chain: c
Length: 464 amino acids
Theoretical weight: 50.64 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1SZP7 (Residues: 1-464; Coverage: 100%)
Gene name: NDUFV1
Sequence domains:
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial Chain: d
Molecule details ›
Chain: d
Length: 249 amino acids
Theoretical weight: 27.44 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SM98 (Residues: 1-231; Coverage: 100%)
Gene name: NDUFV2
Sequence domains: Thioredoxin-like [2Fe-2S] ferredoxin
NADH-ubiquinone oxidoreductase chain 1 Chain: e
Molecule details ›
Chain: e
Length: 318 amino acids
Theoretical weight: 35.67 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: O79874 (Residues: 1-318; Coverage: 100%)
Gene names: MT-ND1, MTND1, NADH1, ND1
Sequence domains: NADH dehydrogenase
NADH-ubiquinone oxidoreductase chain 2 Chain: f
Molecule details ›
Chain: f
Length: 347 amino acids
Theoretical weight: 39.08 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: O79875 (Residues: 1-347; Coverage: 100%)
Gene names: MT-ND2, MTND2, NADH2, ND2
Sequence domains:
NADH-ubiquinone oxidoreductase chain 3 Chain: g
Molecule details ›
Chain: g
Length: 115 amino acids
Theoretical weight: 13 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: O79880 (Residues: 1-115; Coverage: 100%)
Gene names: MT-ND3, MTND3, NADH3, ND3
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
NADH-ubiquinone oxidoreductase chain 4 Chain: h
Molecule details ›
Chain: h
Length: 459 amino acids
Theoretical weight: 51.86 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: O79881 (Residues: 1-459; Coverage: 100%)
Gene names: MT-ND4, MTND4, NADH4, ND4
Sequence domains:
NADH-ubiquinone oxidoreductase chain 4L Chain: i
Molecule details ›
Chain: i
Length: 98 amino acids
Theoretical weight: 10.83 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P56632 (Residues: 1-98; Coverage: 100%)
Gene names: MT-ND4L, MTND4L, NADH4L, ND4L
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
NADH-ubiquinone oxidoreductase chain 5 Chain: j
Molecule details ›
Chain: j
Length: 606 amino acids
Theoretical weight: 68.7 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q9TDR1 (Residues: 1-606; Coverage: 100%)
Gene names: MT-ND5, MTND5, NADH5, ND5
Sequence domains:
NADH-ubiquinone oxidoreductase chain 6 Chains: k, l
Molecule details ›
Chains: k, l
Length: 175 amino acids
Theoretical weight: 19.02 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: O79882 (Residues: 1-175; Coverage: 100%)
Gene names: MT-ND6, MTND6, NADH6, ND6
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase chain 6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 Chain: m
Molecule details ›
Chain: m
Length: 84 amino acids
Theoretical weight: 9.23 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1VPG4 (Residues: 86-169; Coverage: 50%)
Gene name: NDUFA3
Sequence domains: NADH dehydrogenase 1 alpha subcomplex subunit 3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 Chain: n
Molecule details ›
Chain: n
Length: 99 amino acids
Theoretical weight: 11.1 KDa
Source organism: Sus scrofa
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 Chain: o
Molecule details ›
Chain: o
Length: 106 amino acids
Theoretical weight: 12.51 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SV23 (Residues: 1-106; Coverage: 100%)
Gene name: NDUFS5
Sequence domains: NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial Chain: p
Molecule details ›
Chain: p
Length: 377 amino acids
Theoretical weight: 42.61 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SL07 (Residues: 10-372; Coverage: 100%)
Gene name: NDUFA9
Sequence domains: NAD dependent epimerase/dehydratase family
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial Chains: q, v
Molecule details ›
Chains: q, v
Length: 357 amino acids
Theoretical weight: 40.48 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SIS9 (Residues: 1-357; Coverage: 100%)
Gene name: NDUFA10
Sequence domains: Deoxynucleoside kinase
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 Chain: r
Molecule details ›
Chain: r
Length: 144 amino acids
Theoretical weight: 16.91 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D1NRT6 (Residues: 1-144; Coverage: 100%)
Gene name: NDUFA13
Sequence domains: GRIM-19 protein
Acyl carrier protein Chains: Aa, t
Molecule details ›
Chains: Aa, t
Length: 156 amino acids
Theoretical weight: 17.33 KDa
Source organism: Sus scrofa
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial Chains: Ai, u
Molecule details ›
Chains: Ai, u
Length: 189 amino acids
Theoretical weight: 21.59 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SGC6 (Residues: 1-189; Coverage: 100%)
Gene name: NDUFB5
Sequence domains: NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial Chain: w
Molecule details ›
Chain: w
Length: 175 amino acids
Theoretical weight: 19.72 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: G8IFA6 (Residues: 1-175; Coverage: 100%)
Sequence domains: NADH dehydrogenase ubiquinone Fe-S protein 4
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial Chain: x
Molecule details ›
Chain: x
Length: 123 amino acids
Theoretical weight: 13.35 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1S031 (Residues: 1-123; Coverage: 100%)
Gene name: NDUFS6
Sequence domains: Zinc-finger domain
Cytochrome c oxidase subunit 3 Chain: 0
Molecule details ›
Chain: 0
Length: 261 amino acids
Theoretical weight: 29.94 KDa
Source organism: Bos taurus
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Chain: 1
Molecule details ›
Chain: 1
Length: 147 amino acids
Theoretical weight: 17.18 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00423 (Residues: 23-169; Coverage: 87%)
Gene names: COX4, COX4I1
Sequence domains: Cytochrome c oxidase subunit IV
Cytochrome c oxidase subunit 5A, mitochondrial Chain: 2
Molecule details ›
Chain: 2
Length: 109 amino acids
Theoretical weight: 12.45 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00426 (Residues: 44-152; Coverage: 72%)
Gene name: COX5A
Sequence domains: Cytochrome c oxidase subunit Va
Cytochrome c oxidase subunit 5B, mitochondrial Chain: 3
Molecule details ›
Chain: 3
Length: 98 amino acids
Theoretical weight: 10.68 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00428 (Residues: 32-129; Coverage: 76%)
Gene name: COX5B
Sequence domains: Cytochrome c oxidase subunit Vb
Cytochrome c oxidase subunit 6A2, mitochondrial Chain: 4
Molecule details ›
Chain: 4
Length: 84 amino acids
Theoretical weight: 9.45 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P07471 (Residues: 13-96; Coverage: 87%)
Gene names: COX6A, COX6A2
Sequence domains: Cytochrome c oxidase subunit VIa
Cytochrome c oxidase subunit 6B1 Chain: 5
Molecule details ›
Chain: 5
Length: 85 amino acids
Theoretical weight: 10.04 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00429 (Residues: 2-86; Coverage: 99%)
Gene names: COX6B, COX6B1
Sequence domains: Cytochrome oxidase c subunit VIb
Cytochrome c oxidase subunit 6C Chain: 6
Molecule details ›
Chain: 6
Length: 73 amino acids
Theoretical weight: 8.49 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P04038 (Residues: 2-74; Coverage: 99%)
Gene name: COX6C
Sequence domains: Cytochrome c oxidase subunit VIc
Cytochrome c oxidase subunit 7A1, mitochondrial Chain: 7
Molecule details ›
Chain: 7
Length: 59 amino acids
Theoretical weight: 6.68 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P07470 (Residues: 22-80; Coverage: 74%)
Gene names: COX7A, COX7A1, COX7AH
Sequence domains: Cytochrome c oxidase subunit VII
Cytochrome c oxidase subunit 7B, mitochondrial Chain: 8
Molecule details ›
Chain: 8
Length: 56 amino acids
Theoretical weight: 6.37 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P13183 (Residues: 25-80; Coverage: 70%)
Gene name: COX7B
Sequence domains: Cytochrome C oxidase chain VIIB
Cytochrome c oxidase subunit 7C, mitochondrial Chain: 9
Molecule details ›
Chain: 9
Length: 47 amino acids
Theoretical weight: 5.45 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00430 (Residues: 17-63; Coverage: 75%)
Gene names: COX7C, COX7CP1
Sequence domains: Cytochrome c oxidase subunit VIIc
Cytochrome c oxidase subunit 8B, mitochondrial Chain: s
Molecule details ›
Chain: s
Length: 46 amino acids
Theoretical weight: 4.97 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P10175 (Residues: 25-70; Coverage: 66%)
Gene names: COX8B, COX8H
Sequence domains: Cytochrome oxidase c subunit VIII
Cytochrome c oxidase subunit 1 Chain: y
Molecule details ›
Chain: y
Length: 514 amino acids
Theoretical weight: 57.07 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00396 (Residues: 1-514; Coverage: 100%)
Gene names: COI, COXI, MT-CO1, MTCO1
Sequence domains: Cytochrome C and Quinol oxidase polypeptide I
Cytochrome c oxidase subunit 2 Chain: z
Molecule details ›
Chain: z
Length: 227 amino acids
Theoretical weight: 26.04 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P68530 (Residues: 1-227; Coverage: 100%)
Gene names: COII, COX2, COXII, MT-CO2, MTCO2
Sequence domains:
NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment Chains: Ab, Ah
Molecule details ›
Chains: Ab, Ah
Length: 134 amino acids
Theoretical weight: 11.42 KDa
Source organism: Sus scrofa
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Chain: Ac
Molecule details ›
Chain: Ac
Length: 70 amino acids
Theoretical weight: 8.09 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: K7GR43 (Residues: 1-70; Coverage: 100%)
Gene name: NDUFA1
Sequence domains: NADH-ubiquinone oxidoreductase MWFE subunit
NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment Chains: Ad, Ao, Ap, Av
Molecule details ›
Chains: Ad, Ao, Ap, Av
Length: 43 amino acids
Theoretical weight: 3.68 KDa
Source organism: Sus scrofa
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 Chain: Ae
Molecule details ›
Chain: Ae
Length: 116 amino acids
Theoretical weight: 13.32 KDa
Source organism: Sus scrofa
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 Chain: Af
Molecule details ›
Chain: Af
Length: 128 amino acids
Theoretical weight: 14.95 KDa
Source organism: Sus scrofa
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 Chain: Ag
Molecule details ›
Chain: Ag
Length: 141 amino acids
Theoretical weight: 14.69 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: I3LGM4 (Residues: 1-141; Coverage: 100%)
Gene name: NDUFA11
Sequence domains: Tim17/Tim22/Tim23/Pmp24 family
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 Chain: Aj
Molecule details ›
Chain: Aj
Length: 176 amino acids
Theoretical weight: 20.94 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: I3LDC3 (Residues: 1-201; Coverage: 88%)
Gene name: NDUFB10
Sequence domains: NADH-ubiquinone oxidoreductase subunit 10
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 Chain: Ak
Molecule details ›
Chain: Ak
Length: 178 amino acids
Theoretical weight: 21.73 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: K7GSE5 (Residues: 43-220; Coverage: 81%)
Gene name: NDUFB9
Sequence domains: Complex 1 protein (LYR family)
NADH dehydrogenase [ubiquinone] 1 subunit C2 Chain: Al
Molecule details ›
Chain: Al
Length: 122 amino acids
Theoretical weight: 14.33 KDa
Source organism: Sus scrofa
Protein MGARP N-terminal domain-containing protein Chain: Am
Molecule details ›
Chain: Am
Length: 76 amino acids
Theoretical weight: 8.63 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1RRC9 (Residues: 1-7, 8-16, 17-55; Coverage: 25%)
Gene name: MGARP
Sequence domains: Mitochondria Localisation Sequence
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 Chain: An
Molecule details ›
Chain: An
Length: 172 amino acids
Theoretical weight: 20.06 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SLR1 (Residues: 78-249; Coverage: 69%)
Gene name: NDUFA8
Sequence domains: CHCH domain
NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment Chains: Aq, As, Aw
Molecule details ›
Chains: Aq, As, Aw
Length: 76 amino acids
Theoretical weight: 6.49 KDa
Source organism: Sus scrofa
NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment Chain: Ar
Molecule details ›
Chain: Ar
Length: 34 amino acids
Theoretical weight: 2.91 KDa
Source organism: Sus scrofa
NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment Chain: At
Molecule details ›
Chain: At
Length: 17 amino acids
Theoretical weight: 1.46 KDa
Source organism: Sus scrofa
NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment Chain: Au
Molecule details ›
Chain: Au
Length: 13 amino acids
Theoretical weight: 1.12 KDa
Source organism: Sus scrofa

Ligands and Environments

10 bound ligands:
Ligand HEM 4 x HEM
Ligand HEC 2 x HEC
Ligand FES 4 x FES
Ligand SF4 6 x SF4
Ligand FMN 1 x FMN
Ligand NDP 1 x NDP
Ligand ZN 1 x ZN
Ligand HEA 2 x HEA
Ligand CU 3 x CU
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 5.4Å
Relevant EMDB volumes: EMD-9534

Quick links

Citations

50 review citations

The assembly, regulation and function of the mitochondrial respiratory chain.
Vercellino et al. (2022)
49 more

11 mentions without citation

Structure and Mechanism of Respiratory III-IV Supercomplexes in Bioenergetic Membranes.
Brzezinski et al. (2021)
10 more