› 5grr

X-ray diffraction
1.45Å resolution

Crystal structure of MCR-1

Released:
DOI: 10.2210/pdb5grr/pdb
PDB entry 5grr coloured by chain, front view.
PDB entry 5grr coloured by chain, side view.
PDB entry 5grr coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
High resolution crystal structure of the catalytic domain of MCR-1.
Ma G, Zhu Y, Yu Z, Ahmad A, Zhang H
OpenAccess logo Sci Rep 6 39540 (2016)
PMID: 28000749

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102665 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Probable phosphatidylethanolamine transferase Mcr-1 Chain: A
Molecule details ›
Chain: A
Length: 325 amino acids
Theoretical weight: 36.18 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A0R6L508 (Residues: 219-541; Coverage: 60%)
Gene names: APZ14_31440, mcr-1, mcr1
Sequence domains: Sulfatase
Structure domains: Alkaline Phosphatase, subunit A

Ligands and Environments

2 bound ligands:
Ligand ZN 3 x ZN
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 47.314Å b: 62.696Å c: 104.831Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.153 0.152 0.177
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Development of New Tools to Detect Colistin-Resistance among Enterobacteriaceae Strains.
Bardet et al. (2018)
4 more

21 mentions without citation

Phosphoethanolamine Transferases as Drug Discovery Targets for Therapeutic Treatment of Multi-Drug Resistant Pathogenic Gram-Negative Bacteria.
Thai et al. (2023)
20 more