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Crystal structure of human acetylcholinesterase in complex with paraoxon and HI6

Source organism: Homo sapiens
Biochemical function: carboxylic ester hydrolase activity
Biological process: positive regulation of cold-induced thermogenesis
Cellular component: side of membrane

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EC 3.1.1.7: Acetylcholinesterase

Reaction catalysed:
Acetylcholine + H(2)O = choline + acetate
Systematic name:
Acetylcholine acetylhydrolase
Alternative Name(s):
  • AcCholE
  • Acetyl.beta-methylcholinesterase
  • Acetylcholine hydrolase
  • Acetylthiocholinesterase
  • Choline esterase I
  • Cholinesterase
  • True cholinesterase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00135
Domain description: Carboxylesterase family
Occurring in:
  1. Acetylcholinesterase
The deposited structure of PDB entry 5hf9 contains 2 copies of Pfam domain PF00135 (Carboxylesterase family) in Acetylcholinesterase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000997
Domain description: Cholinesterase
Occurring in:
  1. Acetylcholinesterase
IPR029058
Domain description: Alpha/Beta hydrolase fold
Occurring in:
  1. Acetylcholinesterase
IPR019826
Domain description: Carboxylesterase type B, active site
Occurring in:
  1. Acetylcholinesterase
IPR019819
Domain description: Carboxylesterase type B, conserved site
Occurring in:
  1. Acetylcholinesterase
IPR002018
Domain description: Carboxylesterase, type B
Occurring in:
  1. Acetylcholinesterase

Structure domain

CATH CATH domain
3.40.50.1820
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: alpha/beta hydrolase
Occurring in:
  1. Acetylcholinesterase
The deposited structure of PDB entry 5hf9 contains 2 copies of CATH domain 3.40.50.1820 (Rossmann fold) in Acetylcholinesterase. Showing 1 copy in chain B.

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