› 5hfl

X-ray diffraction
2.29Å resolution

Gp41-targeting HIV-1 fusion inhibitors with helical Ile-Asp-Leu tail

Released:
DOI: 10.2210/pdb5hfl/pdb
PDB entry 5hfl coloured by chain, front view.
PDB entry 5hfl coloured by chain, side view.
PDB entry 5hfl coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Rational improvement of gp41-targeting HIV-1 fusion inhibitors: an innovatively designed Ile-Asp-Leu tail with alternative conformations.
Zhu Y, Su S, Qin L, Wang Q, Shi L, Ma Z, Tang J, Jiang S, Lu L, Ye S, Zhang R
Sci Rep 6 31983 (2016)
PMID: 27666394

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137976 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein gp41 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 75 amino acids
Theoretical weight: 8.64 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P04578 (Residues: 546-653; Coverage: 8%)
Gene name: env
Sequence domains: Retroviral envelope protein
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P21
Unit cell:
a: 42.449Å b: 114.471Å c: 42.936Å
α: 90° β: 91.8° γ: 90°
R-values:
R R work R free
0.219 0.214 0.263
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Development of Protein- and Peptide-Based HIV Entry Inhibitors Targeting gp120 or gp41.
Pu et al. (2019)
8 other articles

1 mention without citation

Rational improvement of gp41-targeting HIV-1 fusion inhibitors: an innovatively designed Ile-Asp-Leu tail with alternative conformations.
Zhu et al. (2016)