› 5hgo

X-ray diffraction
2Å resolution

Hexameric HIV-1 CA R18G mutant

Released:
DOI: 10.2210/pdb5hgo/pdb
PDB entry 5hgo coloured by chain, front view.
PDB entry 5hgo coloured by chain, side view.
PDB entry 5hgo coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis.
Jacques DA, McEwan WA, Hilditch L, Price AJ, Towers GJ, James LC
OpenAccess logo Nature 536 349-53 (2016)
PMID: 27509857

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146190 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein p24 Chain: A
Molecule details ›
Chain: A
Length: 231 amino acids
Theoretical weight: 25.36 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P12493 (Residues: 133-363; Coverage: 46%)
Gene name: gag
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P6
Unit cell:
a: 90.81Å b: 90.81Å c: 56.88Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.205 0.221
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

32 review citations

Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response.
Wan et al. (2020)
31 more

1 mention without citation

HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis.
Jacques et al. (2016)