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Murine endoplasmic reticulum alpha-glucosidase II with bound substrate analogue

Source organism: Mus musculus
Biochemical function: Glc2Man9GlcNAc2 oligosaccharide glucosidase activity
Biological process: N-glycan processing
Cellular component: intracellular membrane-bounded organelle

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EC 3.2.1.207: Mannosyl-oligosaccharide alpha-1,3-glucosidase

Reaction catalysed:
Glc(2)Man(9)GlcNAc(2)-[protein] + H(2)O = GlcMan(9)GlcNAc(2)-[protein] + beta-D-glucopyranose
Systematic name:
Glc(2)Man(9)GlcNAc(2)-[protein] 3-alpha-glucohydrolase (configuration-inverting)
Alternative Name(s):
  • Alpha-glucosidase II
  • ER glucosidase II
  • GANAB (gene name)
  • GTB1 (gene name)
  • PRKCSH (gene name)
  • ROT2 (gene name)
  • Trimming glucosidase II

GO terms

Sequence families

Pfam Protein families (Pfam)
PF12999
Domain description: Glucosidase II beta subunit-like
Occurring in:
  1. Glucosidase 2 subunit beta
The deposited structure of PDB entry 5hjo contains 2 copies of Pfam domain PF12999 (Glucosidase II beta subunit-like) in Glucosidase 2 subunit beta. Showing 1 copy in chain B.

PF21365
Domain description: Glycosyl hydrolase family 31 C-terminal domain
Occurring in:
  1. Neutral alpha-glucosidase AB
The deposited structure of PDB entry 5hjo contains 2 copies of Pfam domain PF21365 (Glycosyl hydrolase family 31 C-terminal domain) in Neutral alpha-glucosidase AB. Showing 1 copy in chain A.

PF01055
Domain description: Glycosyl hydrolases family 31 TIM-barrel domain
Occurring in:
  1. Neutral alpha-glucosidase AB
The deposited structure of PDB entry 5hjo contains 2 copies of Pfam domain PF01055 (Glycosyl hydrolases family 31 TIM-barrel domain) in Neutral alpha-glucosidase AB. Showing 1 copy in chain A.

PF13802
Domain description: Glycosyl hydrolase 31 N-terminal galactose mutarotase-like domain
Occurring in:
  1. Neutral alpha-glucosidase AB
The deposited structure of PDB entry 5hjo contains 2 copies of Pfam domain PF13802 (Glycosyl hydrolase 31 N-terminal galactose mutarotase-like domain) in Neutral alpha-glucosidase AB. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036055
Domain description: LDL receptor-like superfamily
Occurring in:
  1. Glucosidase 2 subunit beta
IPR013780
Domain description: Glycosyl hydrolase, all-beta
Occurring in:
  1. Neutral alpha-glucosidase AB
IPR028146
Domain description: Glucosidase II beta subunit, N-terminal
Occurring in:
  1. Glucosidase 2 subunit beta
IPR039794
Domain description: Glucosidase II beta subunit-like
Occurring in:
  1. Glucosidase 2 subunit beta
IPR030459
Domain description: Glycosyl hydrolases family 31, conserved site
Occurring in:
  1. Neutral alpha-glucosidase AB
IPR030458
Domain description: Glycosyl hydrolases family 31, active site
Occurring in:
  1. Neutral alpha-glucosidase AB
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. Neutral alpha-glucosidase AB
IPR000322
Domain description: Glycoside hydrolase family 31, TIM barrel domain
Occurring in:
  1. Neutral alpha-glucosidase AB
IPR025887
Domain description: Glycoside hydrolase family 31, N-terminal domain
Occurring in:
  1. Neutral alpha-glucosidase AB
IPR011013
Domain description: Galactose mutarotase-like domain superfamily
Occurring in:
  1. Neutral alpha-glucosidase AB

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