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Crystal structure of a tankyrase 1-telomere repeat factor 1 complex.

Li B, Qiao R, Wang Z, Zhou W, Li X, Xu W, Rao Z
Acta Crystallogr F Struct Biol Commun 72 320-7 (2016)
Cited: 14 times
EuropePMC logo PMID: 27050267

Abstract

Telomere repeat factor 1 (TRF1) is a subunit of shelterin (also known as the telosome) and plays a critical role in inhibiting telomere elongation by telomerase. Tankyrase 1 (TNKS1) is a poly(ADP-ribose) polymerase that regulates the activity of TRF1 through poly(ADP-ribosyl)ation (PARylation). PARylation of TRF1 by TNKS1 leads to the release of TRF1 from telomeres and allows telomerase to access telomeres. The interaction between TRF1 and TNKS1 is thus important for telomere stability and the mitotic cell cycle. Here, the crystal structure of a complex between the N-terminal acidic domain of TRF1 (residues 1-55) and a fragment of TNKS1 covering the second and third ankyrin-repeat clusters (ARC2-3) is presented at 2.2 Å resolution. The TNKS1-TRF1 complex crystals were optimized using an `oriented rescreening' strategy, in which the initial crystallization condition was used as a guide for a second round of large-scale sparse-matrix screening. This crystallographic and biochemical analysis provides a better understanding of the TRF1-TNKS1 interaction and the three-dimensional structure of the ankyrin-repeat domain of TNKS.

Reviews - 5hkp mentioned but not cited (1)

  1. Multifunctionality of the Telomere-Capping Shelterin Complex Explained by Variations in Its Protein Composition. Ghilain C, Gilson E, Giraud-Panis MJ. Cells 10 1753 (2021)

Articles - 5hkp mentioned but not cited (3)

  1. Structural basis for tankyrase-RNF146 interaction reveals noncanonical tankyrase-binding motifs. DaRosa PA, Klevit RE, Xu W. Protein Sci 27 1057-1067 (2018)
  2. Crystal structure of a tankyrase 1-telomere repeat factor 1 complex. Li B, Qiao R, Wang Z, Zhou W, Li X, Xu W, Rao Z. Acta Crystallogr F Struct Biol Commun 72 320-327 (2016)
  3. Molecular Architecture of Full-length TRF1 Favors Its Interaction with DNA. Boskovic J, Martinez-Gago J, Mendez-Pertuz M, Buscato A, Martinez-Torrecuadrada JL, Blasco MA. J Biol Chem 291 21829-21835 (2016)


Reviews citing this publication (5)

  1. PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification. Langelier MF, Eisemann T, Riccio AA, Pascal JM. Curr Opin Struct Biol 53 187-198 (2018)
  2. Poly(ADP-ribose) polymerase enzymes and the maintenance of genome integrity. Eisemann T, Pascal JM. Cell Mol Life Sci 77 19-33 (2020)
  3. Telomere Length: A Potential Biomarker for the Risk and Prognosis of Stroke. Tian Y, Wang S, Jiao F, Kong Q, Liu C, Wu Y. Front Neurol 10 624 (2019)
  4. Poly(ADP-ribose)-dependent ubiquitination and its clinical implications. Vivelo CA, Ayyappan V, Leung AKL. Biochem Pharmacol 167 3-12 (2019)
  5. Tankyrases as modulators of pro-tumoral functions: molecular insights and therapeutic opportunities. Zamudio-Martinez E, Herrera-Campos AB, Muñoz A, Rodríguez-Vargas JM, Oliver FJ. J Exp Clin Cancer Res 40 144 (2021)

Articles citing this publication (5)

  1. Tankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage. Yang L, Sun L, Teng Y, Chen H, Gao Y, Levine AS, Nakajima S, Lan L. Nucleic Acids Res 45 3906-3921 (2017)
  2. Structural and functional analysis of parameters governing tankyrase-1 interaction with telomeric repeat-binding factor 1 and GDP-mannose 4,6-dehydratase. Eisemann T, Langelier MF, Pascal JM. J Biol Chem 294 14574-14590 (2019)
  3. Structure, dynamics, and regulation of TRF1-TIN2-mediated trans- and cis-interactions on telomeric DNA. Pan H, Kaur P, Barnes R, Detwiler AC, Sanford SL, Liu M, Xu P, Mahn C, Tang Q, Hao P, Bhattaram D, You C, Gu X, Lu W, Piehler J, Xu G, Weninger K, Riehn R, Opresko PL, Wang H. J Biol Chem 297 101080 (2021)
  4. Solution NMR assignment of the ARC4 domain of human tankyrase 2. Zaleska M, Pollock K, Collins I, Guettler S, Pfuhl M. Biomol NMR Assign 13 255-260 (2019)
  5. Leukocyte telomere length, allelic variations in related genes and risk of coronary heart disease in people with long-standing type 1 diabetes. Sanchez M, Kannengiesser C, Hoang S, Potier L, Fumeron F, Venteclef N, Scheen A, Gautier JF, Hadjadj S, Marre M, Roussel R, Mohammedi K, Velho G. Cardiovasc Diabetol 21 206 (2022)


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