› 5hu8

X-ray diffraction
2.45Å resolution

The crystal structure of hemagglutinin from A/Sichuan/26221/2014 (H5N6) influenza virus

Released:
DOI: 10.2210/pdb5hu8/pdb
PDB entry 5hu8 coloured by chain, front view.
PDB entry 5hu8 coloured by chain, side view.
PDB entry 5hu8 coloured by chain, top view.
Source organism: unidentified influenza virus
Primary publication:
Molecular Characterizations of Surface Proteins Hemagglutinin and Neuraminidase from Recent H5Nx Avian Influenza Viruses.
Yang H, Carney PJ, Mishin VP, Guo Z, Chang JC, Wentworth DE, Gubareva LV, Stevens J
J Virol 90 5770-5784 (2016)
PMID: 27053557

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-103169 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Hemagglutinin Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 334 amino acids
Theoretical weight: 37.83 KDa
Source organism: unidentified influenza virus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A0A182DWE0 (Residues: 1-334; Coverage: 100%)
Sequence domains: Haemagglutinin
Structure domains:
Hemagglutinin HA2 Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 181 amino acids
Theoretical weight: 20.88 KDa
Source organism: unidentified influenza virus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A0A182DWE1 (Residues: 1-181; Coverage: 100%)
Sequence domains: Haemagglutinin
Structure domains: Hemagglutinin Ectodomain; Chain B

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 89.505Å b: 104.418Å c: 215.692Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.191 0.227
Expression system: Trichoplusia ni

Quick links

Citations

4 review citations

Pandemic potential of highly pathogenic avian influenza clade 2.3.4.4 A(H5) viruses.
Yamaji et al. (2020)
3 more

3 mentions without citation

Molecular Characterizations of Surface Proteins Hemagglutinin and Neuraminidase from Recent H5Nx Avian Influenza Viruses.
Yang et al. (2016)
2 more