› 5hw8

X-ray diffraction
2.86Å resolution

Candida albicans FKBP12 P104G protein bound with FK506 in C2 space group

Released:
DOI: 10.2210/pdb5hw8/pdb
PDB entry 5hw8 coloured by chain, front view.
PDB entry 5hw8 coloured by chain, side view.
PDB entry 5hw8 coloured by chain, top view.
Source organism: Candida albicans SC5314
Primary publication:
Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.
Tonthat NK, Juvvadi PR, Zhang H, Lee SC, Venters R, Spicer L, Steinbach WJ, Heitman J, Schumacher MA
OpenAccess logo mBio 7 e00492-16 (2016)
PMID: 27118592

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151302 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
FK506-binding protein 1 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 122 amino acids
Theoretical weight: 13.02 KDa
Source organism: Candida albicans SC5314
Expression system: Escherichia coli
UniProt:
  • Canonical: P28870 (Residues: 3-124; Coverage: 98%)
Gene names: CAALFM_C702570CA, CaJ7.0299, CaO19.11186, CaO19.13810, CaO19.3702, CaO19.6452, RBP1, RBP11, RBP12, RBP2
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase
Structure domains: Chitinase A; domain 3

Ligands and Environments

1 bound ligand:
Ligand FK5 8 x FK5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: C2
Unit cell:
a: 115.423Å b: 84.184Å c: 116.724Å
α: 90° β: 109.81° γ: 90°
R-values:
R R work R free
0.247 0.244 0.285
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach.
Juvvadi et al. (2017)
5 more

2 mentions without citation

The complete structure of the human TFIIH core complex.
Greber et al. (2019)
1 more