Function and Biology

Crystal structure Mycobacterium tuberculosis CYP121 in complex with inhibitor fragment 6

Source organism: Mycobacterium tuberculosis
Biochemical function: carbon monoxide binding
Biological process: cholesterol catabolic process
Cellular component: cytoplasm

EC 1.14.19.70: Mycocyclosin synthase

Reaction catalysed:
Cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) = mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H(2)O
Systematic name:
Cyclo(L-tyrosyl-L-tyrosyl),reduced ferredoxin:oxygen oxidoreductase (diarylbridge-forming)
Alternative Name(s):
  • CYP121
  • Rv2276 (gene name)

Sequence family

Pfam Protein family (Pfam)
PF00067
Domain description: Cytochrome P450
Occurring in:
  1. Mycocyclosin synthase
The deposited structure of PDB entry 5ibj contains 1 copy of Pfam domain PF00067 (Cytochrome P450) in Mycocyclosin synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002397
Domain description: Cytochrome P450, B-class
Occurring in:
  1. Mycocyclosin synthase
IPR036396
Domain description: Cytochrome P450 superfamily
Occurring in:
  1. Mycocyclosin synthase
IPR017972
Domain description: Cytochrome P450, conserved site
Occurring in:
  1. Mycocyclosin synthase
IPR001128
Domain description: Cytochrome P450
Occurring in:
  1. Mycocyclosin synthase

Structure domain

CATH CATH domain
1.10.630.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Cytochrome p450
Homology: Cytochrome P450
Occurring in:
  1. Mycocyclosin synthase
The deposited structure of PDB entry 5ibj contains 1 copy of CATH domain 1.10.630.10 (Cytochrome p450) in Mycocyclosin synthase. Showing 1 copy in chain A.