› 5ije

X-ray diffraction
2.4Å resolution

Crystal structure of Equine Serum Albumin in the presence of 30 mM zinc at pH 7.4

Released:
DOI: 10.2210/pdb5ije/pdb
PDB entry 5ije coloured by chain, front view.
PDB entry 5ije coloured by chain, side view.
PDB entry 5ije coloured by chain, top view.
Source organism: Equus caballus
Primary publication:
Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins.
Handing KB, Shabalin IG, Kassaar O, Khazaipoul S, Blindauer CA, Stewart AJ, Chruszcz M, Minor W
OpenAccess logo Chem Sci 7 6635-6648 (2016)
PMID: 28567254

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153012 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chain: A
Molecule details ›
Chain: A
Length: 583 amino acids
Theoretical weight: 65.77 KDa
Source organism: Equus caballus
UniProt:
  • Canonical: P35747 (Residues: 25-607; Coverage: 99%)
Gene name: ALB
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

2 bound ligands:
Ligand ZN 13 x ZN
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P61
Unit cell:
a: 94.384Å b: 94.384Å c: 141.905Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.195 0.255

Quick links

Citations

13 review citations

Cisplatin and beyond: molecular mechanisms of action and drug resistance development in cancer chemotherapy.
Makovec T. (2019)
12 more

1 mention without citation

Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins.
Handing et al. (2016)