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Crystal structure of O-acetylhomoserine sulfhydrolase from Brucella melitensis at 2.0 A resolution

Source organism: Brucella melitensis bv. 1 str. 16M
Biochemical function: pyridoxal phosphate binding
Biological process: transsulfuration
Cellular component: cytoplasm

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EC 2.5.1.48: Cystathionine gamma-synthase

Reaction catalysed:
O(4)-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate
Systematic name:
O(4)-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase
Alternative Name(s):
  • 4-O-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase
  • Cystathionine synthase
  • Cystathionine synthetase
  • Homoserine O-transsuccinylase
  • Homoserine transsuccinylase
  • O-succinyl-L-homoserine succinate-lyase (adding cysteine)
  • O-succinylhomoserine (thiol)-lyase
  • O-succinylhomoserine synthase
  • O-succinylhomoserine synthetase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01053
Domain description: Cys/Met metabolism PLP-dependent enzyme
Occurring in:
  1. Cystathionine gamma-synthase
The deposited structure of PDB entry 5ijg contains 2 copies of Pfam domain PF01053 (Cys/Met metabolism PLP-dependent enzyme) in Cystathionine gamma-synthase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000277
Domain description: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
Occurring in:
  1. Cystathionine gamma-synthase
IPR015422
Domain description: Pyridoxal phosphate-dependent transferase, small domain
Occurring in:
  1. Cystathionine gamma-synthase
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. Cystathionine gamma-synthase
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. Cystathionine gamma-synthase

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