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Cryo-EM structure of GluN1/GluN2B NMDA receptor in the glutamate/glycine-bound conformation

Source organism: Xenopus laevis
Biochemical function: signaling receptor activity
Biological process: monoatomic ion transport
Cellular component: membrane

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00060
Domain description: Ligand-gated ion channel
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2B
The deposited structure of PDB entry 5iou contains 2 copies of Pfam domain PF00060 (Ligand-gated ion channel) in Glutamate receptor ionotropic, NMDA 1. Showing 1 copy in chain A.
The deposited structure of PDB entry 5iou contains 2 copies of Pfam domain PF00060 (Ligand-gated ion channel) in Glutamate receptor ionotropic, NMDA 2B. Showing 1 copy in chain C [auth B].

PF10613
Domain description: Ligated ion channel L-glutamate- and glycine-binding site
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2B
The deposited structure of PDB entry 5iou contains 2 copies of Pfam domain PF10613 (Ligated ion channel L-glutamate- and glycine-binding site) in Glutamate receptor ionotropic, NMDA 1. Showing 1 copy in chain A.
The deposited structure of PDB entry 5iou contains 2 copies of Pfam domain PF10613 (Ligated ion channel L-glutamate- and glycine-binding site) in Glutamate receptor ionotropic, NMDA 2B. Showing 1 copy in chain C [auth B].

PF01094
Domain description: Receptor family ligand binding region
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2B
The deposited structure of PDB entry 5iou contains 4 copies of Pfam domain PF01094 (Receptor family ligand binding region) in Glutamate receptor ionotropic, NMDA 1. Showing 2 copies in chain A.
The deposited structure of PDB entry 5iou contains 2 copies of Pfam domain PF01094 (Receptor family ligand binding region) in Glutamate receptor ionotropic, NMDA 2B. Showing 1 copy in chain C [auth B].

InterPro InterPro annotations
IPR001508
Domain description: Ionotropic glutamate receptor, metazoa
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2B
IPR019594
Domain description: Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2B
IPR001320
Domain description: Ionotropic glutamate receptor, C-terminal
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2B
IPR001828
Domain description: Receptor, ligand binding region
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2B
IPR015683
Domain description: Ionotropic glutamate receptor
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2B
IPR028082
Domain description: Periplasmic binding protein-like I
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2B

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