› 5ise

X-ray diffraction
2.1Å resolution

Crystal structure of mouse CARM1 in complex with inhibitor SA0649

Released:
DOI: 10.2210/pdb5ise/pdb
PDB entry 5ise coloured by chain, front view.
PDB entry 5ise coloured by chain, side view.
PDB entry 5ise coloured by chain, top view.
Source organism: Mus musculus
Entry authors: Cura V, Marechal N, Mailliot J, Troffer-Charlier N, Hassenboehler P, Wurtz JM, Bonnefond L, Cavarelli J

Function and Biology Details

Reaction catalysed: 
(1a) S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N(omega)-methyl-L-arginine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-578082 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone-arginine methyltransferase CARM1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 361 amino acids
Theoretical weight: 40.85 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9WVG6 (Residues: 130-487; Coverage: 59%)
Gene names: Carm1, Prmt4
Sequence domains:
Structure domains:

Ligands and Environments

6 bound ligands:
Ligand 6D2 4 x 6D2
Ligand EDO 4 x EDO
Ligand PGE 1 x PGE
Ligand DXE 4 x DXE
Ligand PEG 4 x PEG
Ligand PE8 1 x PE8
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P21212
Unit cell:
a: 74.74Å b: 98.296Å c: 206.234Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.153 0.151 0.2
Expression system: Spodoptera frugiperda

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