› 5j5e

X-ray diffraction
2.8Å resolution

crystal structure of antigen-ERAP1 domain complex

Released:
DOI: 10.2210/pdb5j5e/pdb
PDB entry 5j5e coloured by chain, front view.
PDB entry 5j5e coloured by chain, side view.
PDB entry 5j5e coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of a polypeptide's C-terminus in complex with the regulatory domain of ER aminopeptidase 1.
Sui L, Gandhi A, Guo HC
Mol Immunol 80 41-49 (2016)
PMID: 27825049

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192727 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endoplasmic reticulum aminopeptidase 1 Chain: A
Molecule details ›
Chain: A
Length: 420 amino acids
Theoretical weight: 48.75 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NZ08 (Residues: 529-941; Coverage: 44%)
Gene names: APPILS, ARTS1, ERAP1, KIAA0525, UNQ584/PRO1154
Sequence domains: ERAP1-like C-terminal domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21
Unit cell:
a: 64.26Å b: 66.85Å c: 66.5Å
α: 90° β: 110.16° γ: 90°
R-values:
R R work R free
0.21 0.207 0.269
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases.
Papakyriakou et al. (2017)
1 more

1 mention without citation

Crystal structure of a polypeptide's C-terminus in complex with the regulatory domain of ER aminopeptidase 1.
Sui et al. (2016)