Function and Biology Details
Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Inhibitor of growth protein, N-terminal histone-binding
- Chromatin modification-related protein Eaf6
- Histone acetyltransferase domain, MYST-type
- ING family
- Enhancer of polycomb protein
- Enhancer of polycomb-like, N-terminal
- Winged helix-like DNA-binding domain superfamily
- MYST, zinc finger domain
1 more domain
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-153730 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Histone acetyltransferase ESA1
Molecule details ›
Chains: A, E, I
Length: 305 amino acids
Theoretical weight: 36.56 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 305 amino acids
Theoretical weight: 36.56 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
- Canonical:
Q08649 (Residues: 141-445; Coverage: 69%)
Sequence domains:
Chromatin modification-related protein EAF6
Molecule details ›
Chains: B, F, J
Length: 113 amino acids
Theoretical weight: 12.92 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
Sequence domains: Histone acetyltransferase subunit NuA4
Length: 113 amino acids
Theoretical weight: 12.92 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
- Canonical: P47128 (Residues: 1-113; Coverage: 100%)
Sequence domains: Histone acetyltransferase subunit NuA4
Enhancer of polycomb-like protein 1
Chromatin modification-related protein YNG2
