EC 1.15.1.1: Superoxide dismutase
Reaction catalysed:
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Systematic name:
Superoxide:superoxide oxidoreductase
Alternative Name(s):
- Copper-zinc superoxide dismutase
- Cu,Zn-SOD
- Cu-Zn superoxide dismutase
- Cuprein
- Cytocuprein
- Erythrocuprein
- Fe-SOD
- Ferrisuperoxide dismutase
- Hemocuprein
- Hepatocuprein
- Mn-SOD
- SOD
- SOD-1
- SOD-2
- SOD-3
- SOD-4
- SODF
- SODS
- Superoxidase dismutase
- Superoxide dismutase I
- Superoxide dismutase II
GO terms
Biochemical function:
- protein-folding chaperone binding
- metal ion binding
- protein homodimerization activity
- identical protein binding
- small GTPase binding
- protein phosphatase 2B binding
- enzyme binding
- oxidoreductase activity
- antioxidant activity
- zinc ion binding
- protein binding
- copper ion binding
- superoxide dismutase activity
Biological process:
- negative regulation of reproductive process
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
- action potential initiation
- response to antipsychotic drug
- reactive oxygen species metabolic process
- cellular response to ATP
- cellular response to cadmium ion
- auditory receptor cell stereocilium organization
- relaxation of vascular associated smooth muscle
- neurofilament cytoskeleton organization
- heart contraction
- regulation of mitochondrial membrane potential
- negative regulation of developmental process
- positive regulation of phagocytosis
- negative regulation of inflammatory response
- hydrogen peroxide biosynthetic process
- response to axon injury
- thymus development
- muscle cell cellular homeostasis
- response to copper ion
- regulation of organ growth
- response to ethanol
- negative regulation of neuron apoptotic process
- positive regulation of MAPK cascade
- regulation of GTPase activity
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- superoxide anion generation
- response to hydrogen peroxide
- regulation of multicellular organism growth
- cellular response to potassium ion
- ectopic germ cell programmed cell death
- cellular response to oxidative stress
- response to carbon monoxide
- regulation of T cell differentiation in thymus
- positive regulation of superoxide anion generation
- peripheral nervous system myelin maintenance
- response to nutrient levels
- removal of superoxide radicals
- neuronal action potential
- transmission of nerve impulse
- gene expression
- response to xenobiotic stimulus
- response to heat
- determination of adult lifespan
- regulation of blood pressure
- retrograde axonal transport
- anterograde axonal transport
- locomotory behavior
- sensory perception of sound
- embryo implantation
- spermatogenesis
- response to oxidative stress
- apoptotic process
- intracellular iron ion homeostasis
- superoxide metabolic process
- glutathione metabolic process
- myeloid cell homeostasis
- response to amphetamine
- retina homeostasis
- placenta development
- positive regulation of cytokine production
- ovarian follicle development
- response to superoxide
- response to reactive oxygen species
Cellular component:
- axon cytoplasm
- extracellular exosome
- neuronal cell body
- protein-containing complex
- dendrite cytoplasm
- cytoplasmic vesicle
- dense core granule
- secretory granule
- plasma membrane
- cytosol
- peroxisome
- lysosome
- mitochondrial matrix
- mitochondrial intermembrane space
- mitochondrion
- cytoplasm
- nucleoplasm
- nucleus
- extracellular space
- extracellular region
Sequence family
Protein family (Pfam)
![The deposited structure of PDB entry 5k02 contains 24 copies of Pfam domain PF00080 (Copper/zinc superoxide dismutase (SODC)) in Superoxide dismutase [Cu-Zn]. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/5k02_1_A_Pfam_PF00080_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5k02</span> contains 24 copies of Pfam domain <span class='highlight'>PF00080 (Copper/zinc superoxide dismutase (SODC))</span> in <span class='highlight'>Superoxide dismutase [Cu-Zn]</span>. Showing 1 copy in chain <span class='highlight'>A</span>.")
InterPro annotations
IPR036423
Domain description:
Superoxide dismutase-like, copper/zinc binding domain superfamily
Occurring in:
Occurring in: