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Crystals structure of Acyl-CoA oxidase-1 in Caenorhabditis elegans, Apo form-II

Source organism: Caenorhabditis elegans
Biochemical function: FAD binding
Biological process: ascaroside biosynthetic process
Cellular component: peroxisomal matrix

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EC 1.3.3.6: Acyl-CoA oxidase

Reaction catalysed:
Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2)
Systematic name:
Acyl-CoA:oxygen 2-oxidoreductase
Alternative Name(s):
  • Acyl coenzyme A oxidase
  • Fatty acyl-CoA oxidase
  • Fatty acyl-coenzyme A oxidase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF01756
Domain description: Acyl-CoA oxidase
Occurring in:
  1. Acyl-coenzyme A oxidase acox-1.1
The deposited structure of PDB entry 5k3h contains 8 copies of Pfam domain PF01756 (Acyl-CoA oxidase) in Acyl-coenzyme A oxidase acox-1.1. Showing 1 copy in chain B.

PF22924
Domain description: Acyl-CoA oxidase, C-alpha1 domain
Occurring in:
  1. Acyl-coenzyme A oxidase acox-1.1

PF14749
Domain description: Acyl-coenzyme A oxidase N-terminal
Occurring in:
  1. Acyl-coenzyme A oxidase acox-1.1
The deposited structure of PDB entry 5k3h contains 8 copies of Pfam domain PF14749 (Acyl-coenzyme A oxidase N-terminal) in Acyl-coenzyme A oxidase acox-1.1. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR036250
Domain description: Acyl-CoA dehydrogenase-like, C-terminal
Occurring in:
  1. Acyl-coenzyme A oxidase acox-1.1
IPR012258
Domain description: Acyl-CoA oxidase
Occurring in:
  1. Acyl-coenzyme A oxidase acox-1.1
IPR002655
Domain description: Acyl-CoA oxidase, C-terminal
Occurring in:
  1. Acyl-coenzyme A oxidase acox-1.1
IPR046373
Domain description: Acyl-CoA oxidase/dehydrogenase, middle domain superfamily
Occurring in:
  1. Acyl-coenzyme A oxidase acox-1.1
IPR009100
Domain description: Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
Occurring in:
  1. Acyl-coenzyme A oxidase acox-1.1
IPR037069
Domain description: Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
Occurring in:
  1. Acyl-coenzyme A oxidase acox-1.1
IPR029320
Domain description: Acyl-coenzyme A oxidase, N-terminal
Occurring in:
  1. Acyl-coenzyme A oxidase acox-1.1

Structure domains

CATH CATH domains
1.20.140.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Butyryl-CoA Dehydrogenase, subunit A; domain 3
Homology: Butyryl-CoA Dehydrogenase, subunit A, domain 3
Occurring in:
  1. Acyl-coenzyme A oxidase acox-1.1
The deposited structure of PDB entry 5k3h contains 16 copies of CATH domain 1.20.140.10 (Butyryl-CoA Dehydrogenase, subunit A; domain 3) in Acyl-coenzyme A oxidase acox-1.1. Showing 2 copies in chain B.
2.40.110.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Butyryl-CoA Dehydrogenase, subunit A; domain 2
Homology: Butyryl-CoA Dehydrogenase, subunit A, domain 2
Occurring in:
  1. Acyl-coenzyme A oxidase acox-1.1
The deposited structure of PDB entry 5k3h contains 8 copies of CATH domain 2.40.110.10 (Butyryl-CoA Dehydrogenase, subunit A; domain 2) in Acyl-coenzyme A oxidase acox-1.1. Showing 1 copy in chain B.
1.10.540.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Butyryl-Coa Dehydrogenase, subunit A; domain 1
Homology: Acyl-CoA dehydrogenase/oxidase, N-terminal domain
Occurring in:
  1. Acyl-coenzyme A oxidase acox-1.1
The deposited structure of PDB entry 5k3h contains 8 copies of CATH domain 1.10.540.10 (Butyryl-Coa Dehydrogenase, subunit A; domain 1) in Acyl-coenzyme A oxidase acox-1.1. Showing 1 copy in chain B.

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