› 5k6w

X-ray diffraction
3.5Å resolution

Sidekick-1 immunoglobulin domains 1-5

Released:
DOI: 10.2210/pdb5k6w/pdb
PDB entry 5k6w coloured by chain, front view.
PDB entry 5k6w coloured by chain, side view.
PDB entry 5k6w coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Molecular basis of sidekick-mediated cell-cell adhesion and specificity.
Goodman KM, Yamagata M, Jin X, Mannepalli S, Katsamba PS, Ahlsén G, Sergeeva AP, Honig B, Sanes JR, Shapiro L
OpenAccess logo Elife 5 (2016)
PMID: 27644106

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-174839 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Protein sidekick-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 481 amino acids
Theoretical weight: 52.87 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q3UH53 (Residues: 78-556; Coverage: 22%)
Gene name: Sdk1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand NAG 5 x NAG
Ligand GOL 2 x GOL
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P212121
Unit cell:
a: 70.14Å b: 152.87Å c: 158.97Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.202 0.251
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Adhesion Protein Structure, Molecular Affinities, and Principles of Cell-Cell Recognition.
Honig et al. (2020)
3 more

4 mentions without citation

Structure and Functions of Sidekicks.
Yamagata M. (2020)
3 more