› 5kae

X-ray diffraction
2.65Å resolution

Crystal structure of human PI3K-gamma in complex with quinoline-containing inhibitor 5g

Released:
DOI: 10.2210/pdb5kae/pdb
PDB entry 5kae coloured by chain, front view.
PDB entry 5kae coloured by chain, side view.
PDB entry 5kae coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Whittington DA, Tang J, Yakowec P

Function and Biology Details

Reactions catalysed: 
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155801 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Chain: A
Molecule details ›
Chain: A
Length: 959 amino acids
Theoretical weight: 109.77 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P48736 (Residues: 144-1102; Coverage: 87%)
Gene name: PIK3CG
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 3 x SO4
Ligand 6RF 1 x 6RF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 143.578Å b: 67.661Å c: 106.197Å
α: 90° β: 95.05° γ: 90°
R-values:
R R work R free
0.204 0.201 0.252
Expression system: Spodoptera frugiperda

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