› 5keq

Electron Microscopy
4.3Å resolution

High resolution cryo-EM maps of Human papillomavirus 16 reveal L2 location and heparin-induced conformational changes

Released:
DOI: 10.2210/pdb5keq/pdb
PDB entry 5keq coloured by chain, front view.
PDB entry 5keq coloured by chain, side view.
PDB entry 5keq coloured by chain, top view.
Source organism: Human papillomavirus type 16
Primary publication:
Cryoelectron Microscopy Maps of Human Papillomavirus 16 Reveal L2 Densities and Heparin Binding Site.
Guan J, Bywaters SM, Brendle SA, Ashley RE, Makhov AM, Conway JF, Christensen ND, Hafenstein S
Structure 25 253-263 (2017)
PMID: 28065506
Related structures: EMD-6619

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 360-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-527273 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major capsid protein L1 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 483 amino acids
Theoretical weight: 53.94 KDa
Source organism: Human papillomavirus type 16
Expression system: Macaca mulatta polyomavirus 1
UniProt:
  • Canonical: P03101 (Residues: 3-485; Coverage: 96%)
Gene name: L1
Sequence domains: L1 (late) protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.3Å
Relevant EMDB volumes: EMD-6619
Expression system: Macaca mulatta polyomavirus 1

Quick links

Citations

10 review citations

Opportunities and challenges for human papillomavirus vaccination in cancer.
Roden et al. (2018)
9 more

4 mentions without citation

Virus Isoelectric Point Estimation: Theories and Methods.
Heffron et al. (2021)
3 more