› 5kvl

X-ray diffraction
1.74Å resolution

Humanized 10G4 anti-leukotriene C4 antibody Fab fragment in complex with leukotriene C4

Released:
DOI: 10.2210/pdb5kvl/pdb
PDB entry 5kvl coloured by chain, front view.
PDB entry 5kvl coloured by chain, side view.
PDB entry 5kvl coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Huxford T, King A, Fleming JK, Wojciak JM

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-231420 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Humanized 10G4 anti-Leukotriene C4 Immunoglobulin G (IgG) heavy chain Fab fragment Chain: H
Molecule details ›
Chain: H
Length: 215 amino acids
Theoretical weight: 22.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Humanized 10G4 anti-Leukotriene C4 Immunoglobulin G (IgG) light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.44 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

5 bound ligands:
Ligand ZN 3 x ZN
Ligand EDO 1 x EDO
Ligand PGE 1 x PGE
Ligand TRS 1 x TRS
Ligand LTX 1 x LTX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21
Unit cell:
a: 51.88Å b: 41.631Å c: 93.126Å
α: 90° β: 104.69° γ: 90°
R-values:
R R work R free
0.192 0.19 0.22
Expression system: Homo sapiens

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