EC 1.5.1.9: Saccharopine dehydrogenase (NAD(+), L-glutamate-forming)
Reaction catalysed:
N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NAD(+) + H(2)O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADH
Systematic name:
N(6)-(L-1,3-dicarboxypropyl)-L-lysine:NAD(+) oxidoreductase (L-glutamate-forming)
Alternative Name(s):
- 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD(+) oxidoreductase (L-glutamate-forming)
- Aminoadipic semialdehyde synthase
- Dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming)
- NAD(+) oxidoreductase (L-2-aminoadipic-delta-semialdehyde and glutamate forming)
- Saccharopin dehydrogenase
EC 1.5.1.8: Saccharopine dehydrogenase (NADP(+), L-lysine-forming)
Reaction catalysed:
N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NADP(+) + H(2)O = L-lysine + 2-oxoglutarate + NADPH
Systematic name:
N(6)-(L-1,3-dicarboxypropyl)-L-lysine:NADP(+) oxidoreductase (L-lysine-forming)
Alternative Name(s):
- 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP(+) oxidoreductase (L-lysine-forming)
- L-lysine-alpha-ketoglutarate reductase
- Lysine-2-oxoglutarate reductase
- Lysine-ketoglutarate reductase
- Lysine:alpha-ketoglutarate:TPNH oxidoreductase (epsilon-N-(gultaryl-2)-L-lysine forming)
- Saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase
GO terms
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence families
Protein families (Pfam)
InterPro annotations
Structure domains
CATH domains
3.30.360.10
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Dihydrodipicolinate Reductase; domain 2
Homology:
Dihydrodipicolinate Reductase; domain 2
Occurring in:
