› 5lc3

X-ray diffraction
2Å resolution

Xray structure of mouse FAM3C ILEI monomer

Released:
DOI: 10.2210/pdb5lc3/pdb
PDB entry 5lc3 coloured by chain, front view.
PDB entry 5lc3 coloured by chain, side view.
PDB entry 5lc3 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The interleukin-like epithelial-mesenchymal transition inducer ILEI exhibits a non-interleukin-like fold and is active as a domain-swapped dimer.
Jansson AM, Csiszar A, Maier J, Nyström AC, Ax E, Johansson P, Schiavone LH
J Biol Chem 292 15501-15511 (2017)
PMID: 28751379

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187569 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein FAM3C Chains: A, B
Molecule details ›
Chains: A, B
Length: 205 amino acids
Theoretical weight: 22.71 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q91VU0 (Residues: 55-227; Coverage: 85%)
Gene names: D6Wsu176e, Fam3c, Ilei
Sequence domains: Interleukin-like EMT inducer

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: C2
Unit cell:
a: 163.839Å b: 31.976Å c: 75.748Å
α: 90° β: 111.55° γ: 90°
R-values:
R R work R free
0.22 0.219 0.241
Expression system: Homo sapiens

Quick links

Citations

1 review citation

TGF-beta signaling in cancer: post-transcriptional regulation of EMT via hnRNP E1.
Howley et al. (2019)
11 other articles

1 mention without citation

The interleukin-like epithelial-mesenchymal transition inducer ILEI exhibits a non-interleukin-like fold and is active as a domain-swapped dimer.
Jansson et al. (2017)