› 5lf9

X-ray diffraction
1.45Å resolution

Crystal structure of human NUDT22

Released:
DOI: 10.2210/pdb5lf9/pdb
PDB entry 5lf9 coloured by chain, front view.
PDB entry 5lf9 coloured by chain, side view.
PDB entry 5lf9 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tallant C, Siejka P, Mathea S, Shrestha L, Krojer T, Srikannathasan V, Elkins JM, Burgess-Brown N, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Huber K, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
UDP-sugar + H(2)O = UMP + alpha-D-aldose 1-phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189690 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Uridine diphosphate glucose pyrophosphatase NUDT22 Chain: A
Molecule details ›
Chain: A
Length: 304 amino acids
Theoretical weight: 32.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BRQ3 (Residues: 1-303; Coverage: 100%)
Gene names: NUDT22, PP11246

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 49.81Å b: 52.114Å c: 101.783Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 0.171 0.207
Expression system: Escherichia coli

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