› 5lgf

Solution NMR

Solution structure of the N-terminal domain of Ogataea polymorpha telomerase reverse transcriptase

Released:
DOI: 10.2210/pdb5lgf/pdb
PDB entry 5lgf coloured by chain, ensemble of 20 models, front view.
PDB entry 5lgf coloured by chain, ensemble of 20 models, side view.
PDB entry 5lgf coloured by chain, ensemble of 20 models, top view.
Source organism: Ogataea polymorpha
Primary publication:
Structure and function of the N-terminal domain of the yeast telomerase reverse transcriptase.
Petrova OA, Mantsyzov AB, Rodina EV, Efimov SV, Hackenberg C, Hakanpää J, Klochkov VV, Lebedev AA, Chugunova AA, Malyavko AN, Zatsepin TS, Mishin AV, Zvereva MI, Lamzin VS, Dontsova OA, Polshakov VI
OpenAccess logo Nucleic Acids Res 46 1525-1540 (2018)
PMID: 29294091

Function and Biology Details

Reaction catalysed: 
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195756 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Telomerase reverse transcriptase Chain: A
Molecule details ›
Chain: A
Length: 159 amino acids
Theoretical weight: 18.58 KDa
Source organism: Ogataea polymorpha
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: R4IT35 (Residues: 1-154; Coverage: 20%)
Gene name: OGATHE_002606

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 74%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Circular RNAs in Cancer: emerging functions in hallmarks, stemness, resistance and roles as potential biomarkers.
Su et al. (2019)
4 more

3 mentions without citation

Structural biology of telomeres and telomerase.
Smith et al. (2020)
2 more