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Structure of GH36 alpha-galactosidase from Thermotoga maritima in a covalent complex with a cyclopropyl carbasugar.

Source organism: Thermotoga maritima
Biochemical function: protein homodimerization activity
Biological process: glycoside catabolic process
Cellular component: not assigned

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EC 3.2.1.22: Alpha-galactosidase

Reaction catalysed:
Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids
Systematic name:
Alpha-D-galactoside galactohydrolase
Alternative Name(s):
  • Alpha-D-galactosidase
  • Alpha-galactosidase A
  • Alpha-galactoside galactohydrolase
  • Melibiase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02065
Domain description: Melibiase
Occurring in:
  1. Alpha-galactosidase
The deposited structure of PDB entry 5m1i contains 1 copy of Pfam domain PF02065 (Melibiase) in Alpha-galactosidase. Showing 1 copy in chain A.

PF22676
Domain description: Alpha-galactosidase, N-terminal
Occurring in:
  1. Alpha-galactosidase

InterPro InterPro annotations
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. Alpha-galactosidase
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. Alpha-galactosidase
IPR011013
Domain description: Galactose mutarotase-like domain superfamily
Occurring in:
  1. Alpha-galactosidase

Structure domains

CATH CATH domains
2.60.40.2760
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulin-like
Occurring in:
  1. Alpha-galactosidase
The deposited structure of PDB entry 5m1i contains 1 copy of CATH domain 2.60.40.2760 (Immunoglobulin-like) in Alpha-galactosidase. Showing 1 copy in chain A.
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. Alpha-galactosidase
The deposited structure of PDB entry 5m1i contains 1 copy of CATH domain 3.20.20.70 (TIM Barrel) in Alpha-galactosidase. Showing 1 copy in chain A.

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